ReviewDocumenta ophthalmologica. Advances in ophthalmology2003
Metabotropic glutamate receptors in vertebrate retina.
Review in Documenta ophthalmologica. Advances in ophthalmology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 24 citations in OpenAlex.
- Beyond the Ligand: Extracellular and Transcellular G Protein-Coupled Receptor Complexes in Physiology and Pharmacology.Pharmacological reviews · 2019Review
- Polybenzyl Glutamate Biocompatible Scaffold Promotes the Efficiency of Retinal Differentiation toward Retinal Ganglion Cell Lineage from Human-Induced Pluripotent Stem Cells.International journal of molecular sciences · 2019Article
- mGluR1 enhances efferent inhibition of inner hair cells in the developing rat cochlea.The Journal of physiology · 2017Article
- Full-field electroretinogram in autism spectrum disorder.Documenta ophthalmologica. Advances in ophthalmology · 2016Article
- Speeding rod recovery improves temporal resolution in the retina.Vision research · 2015Article
- Mathematical modeling the neuroregulation of blood pressure using a cognitive top-down approach.North American journal of medical sciences · 2010Article
- Kynurenic acid synthesis in bovine retinal slices--effect of glutamate agonists.Journal of neural transmission (Vienna, Austria : 1996) · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A striking feature in visual information processing is the fact that the primary signaling elements, the rods and the cones, are hyperpolarized and thus inhibited by light, the physiological stimulus. Light effectively shuts down neurotransmitter release by the photoreceptors onto the second-order retinal neurons. It has long been recognized that a sign-inverting synapse utilizing a specialized receptor is required to translate the inhibitory photoreceptor response into an excitatory signal suitable for transmission to the visual cortex. Although the first clues to the underlying mechanism were discovered in the 1970s, the actual receptor initiating the sign inversion in the ON bipolar cells was only identified in 1993. This receptor was found to belong to the family of metabotropic glutamate receptors (mGluRs) and is referred to as mGluR6. Subsequent studies have focused on the intracellular transduction pathway allowing mGluR6 to mediate a hyperpolarizing response to the neurotransmitter glutamate. The mGluR family of receptors comprises seven additional members, all of which are also found in retinal cells. Their function is to modulate rather than to transmit visual signals. In this brief overview, I describe the basic properties of mGluRs and summarize their roles in retinal signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.