ReviewJournal of neuro-oncology2003
A new approach to the diagnosis and treatment of intravascular lymphoma.
Review in Journal of neuro-oncology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The natural history of intravascular lymphomatosis.Cancer medicine · 2014Pooled it
- The natural history of neurolymphomatosis.BJC reports · 2024Article
- Article
- Rare central nervous system lymphomas.British journal of haematology · 2022Review
- Different imaging patterns of PCNSL and IVL: a case report.BMC neurology · 2019Article
- Intravascular lymphoma as a Potential Cause of Recurrent Embolic Stroke of Undetermined Source.Journal of clinical neurology (Seoul, Korea) · 2019Article
- Intravascular Lymphoma in the CNS: Options for Treatment.Current treatment options in neurology · 2017Review
- A Small Case Series of Intravascular Large B-Cell Lymphoma with Unexpected Findings: Subset of Cases with Concomitant Extravascular Central Nervous System (CNS) Involvement Mimicking Primary CNS Lymphoma.Journal of pathology and translational medicine · 2017Article
- A case of intravascular lymphoma presenting as myelopathy diagnosed with a skin biopsy.Surgical neurology international · 2015Article
- A case of large B-cell intravascular lymphoma in the brain.Surgical neurology international · 2013Article
- Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy.Experimental hematology & oncology · 2012Article
- Intravascular lymphoma of the central nervous system presenting as multiple cerebral infarctions.Nagoya journal of medical science · 2012Article
- Cauda equina syndrome secondary to intravascular lymphoma.Neurology. Clinical practice · 2012Article
- Intravascular lymphomatosis of the brain in a patient with myelodysplastic syndrome.Nature reviews. Neurology · 2009Article
- Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption.BMJ case reports · 2009Article
- Intravascular lymphoma: magnetic resonance imaging correlates of disease dynamics within the central nervous system.Journal of neurology, neurosurgery, and psychiatry · 2005Article
- Modern techniques of magnetic resonance in the evaluation of primary central nervous system lymphoma: contributions to the diagnosis and differential diagnosis.Revista brasileira de hematologia e hemoterapiaArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In intravascular lymphoma (IVL) tumor cells are initially restricted to vascular lumina. Neurological syndromes predominate and are caused by ischemia as well as tumor infiltration into the nervous system. Ante mortem diagnosis is challenging and frequently impossible. Chemotherapy is effective if started prior to ischemic damage. Over a three year period, we have diagnosed IVL in seven patients. Tissue diagnosis could be accomplished in only three cases. Forthose in whom tissue diagnosis failed we based our diagnosis on clinical presentation, typical magnetic resonance imaging findings, spinal fluid cytopathology, and molecular analyses. Six patients were treated with methotrexate chemotherapy alone or in combination with CHOP. Three patients are in complete remission 9-20 months after initial diagnosis. Another patient achieved a partial response. Two patients died due to progressive disease shortly after initiation of treatment. Grade III toxicity was observed in only 4 of 61 cycles. Based on a small retrospective series of patients, we conclude that methotrexate is a well tolerated and effective agent for the treatment of IVL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.