ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2003
HP1beta and HP1gamma, but not HP1alpha, decorate the entire XY body during human male meiosis.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Sex body: A nest of protein mixture.Frontiers in cell and developmental biology · 2023Review
- Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis.Cellular and molecular life sciences : CMLS · 2021Review
- A Hypothesis: Linking Phase Separation to Meiotic Sex Chromosome Inactivation and Sex-Body Formation.Frontiers in cell and developmental biology · 2021Review
- TH2BS11ph histone mark is enriched in the unsynapsed axes of the XY body and predominantly associates with H3K4me3-containing genomic regions in mammalian spermatocytes.Epigenetics & chromatin · 2019Article
- SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice.Developmental cell · 2018Article
- Human postmeiotic sex chromatin and its impact on sex chromosome evolution.Genome research · 2012Article
- Function of the sex chromosomes in mammalian fertility.Cold Spring Harbor perspectives in biology · 2011Review
- Heterochromatin and histone modifications in the germline-restricted chromosome of the zebra finch undergoing elimination during spermatogenesis.Chromosoma · 2010Article
- In human pachytene spermatocytes, SUMO protein is restricted to the constitutive heterochromatin.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- The X and Y chromosomes assemble into H2A.Z-containing [corrected] facultative heterochromatin [corrected] following meiosis.Molecular and cellular biology · 2006Article
- Article
- Viability of X-autosome translocations in mammals: an epigenomic hypothesis from a rodent case-study.Chromosoma · 2004Article
- High- and low-mobility populations of HP1 in heterochromatin of mammalian cells.Molecular biology of the cell · 2004Article
- Formation of facultative heterochromatin in the absence of HP1.The EMBO journal · 2003Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During meiosis in male mammals, the X and Y chromosomes become heterochromatic and transcriptionally silent, and form the XY body. Although the HP1 proteins are known to be involved in the packaging of chromosomal DNA into repressive heterochromatin domains, their involvement in facultative heterochromatinization has not been precisely determined. Here, we analyse, for the first time in humans, the subcellular distribution of the heterochromatin protein HP1alpha, HP1beta and HP1gamma isoforms, in male pachytene spermatocytes, and the XY body facultative heterochromatin in particular. Our results demonstrate that HP1beta and HP1gamma, but not the HP1alpha isoforms, decorate the entire XY body in half the pachytene nuclei observed. In some nuclei, the XY body appears to be only partially labelled. In these cases, the HP1beta and HP1gamma signals are adjacent to the Yq12 constitutive heterochromatin and signal appears to originate in this region before spreading over the entire XY body. This distribution suggests that HP1beta and HP1gamma proteins, which are components of the constitutive heterochromatin, may also be involved in the facultative heterochromatinization of the XY body. Nevertheless, their absence from the early pachytene substage, even though the XY body is already condensed, suggests that these proteins are not involved in the initiation of this process.
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