ArticleNeurochemical research2003
Catecholaminergic neurons in the rat intrinsic cardiac nervous system.
Article in Neurochemical research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Recording plasticity in neuronal activity in the rodent intrinsic cardiac nervous system using calcium imaging techniques.Frontiers in synaptic neuroscience · 2023Article
- From Mice to Mainframes: Experimental Models for Investigation of the Intracardiac Nervous System.Journal of cardiovascular development and disease · 2021Review
- Novel cardiac cell subpopulations: Pnmt-derived cardiomyocytes.Open biology · 2020Review
- Transcriptomic evidence that cortisol alters perinatal epicardial adipose tissue maturation.American journal of physiology. Endocrinology and metabolism · 2019Article
- Substance P Receptor in the Rat Heart and Regulation of Its Expression in Long-Term Diabetes.Frontiers in physiology · 2018Article
- Synaptic Plasticity in Cardiac Innervation and Its Potential Role in Atrial Fibrillation.Frontiers in physiology · 2018Review
- Innervation of the rabbit cardiac ventricles.Journal of anatomy · 2016Article
- Therapeutic potential of Pnmt+ primer cells for neuro/myocardial regeneration.American journal of stem cells · 2013Review
- Nerves projecting from the intrinsic cardiac ganglia of the pulmonary veins modulate sinoatrial node pacemaker function.Cardiovascular research · 2013Article
- Expression and distribution of dopamine transporter in cardiac tissues of the guinea pig.Neurochemical research · 2011Article
- Modulation of rat parasympathetic cardiac ganglion phenotype and NGF synthesis by adrenergic nerves.Autonomic neuroscience : basic & clinical · 2009Article
- Effect of stellate ganglionectomy on basal cardiovascular function and responses to beta1-adrenoceptor blockade in the rat.American journal of physiology. Heart and circulatory physiology · 2008Article
- Cardiac norepinephrine transporter protein expression is inversely correlated to chamber norepinephrine content.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Plasma catecholamines and ischemic heart disease.Clinical cardiology · 2007Article
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoreactivities (IR) for catecholamine-synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DbetaH), phenylethanolamine N-methyl transferase (PNMT), serotonin-synthesizing enzyme tryptophan hydroxylase, and neuropeptide Y were investigated in the intrinsic cardiac nervous system of 27-40-day-old rats using fluorescent immunohistochemistry. Individual neurons were identified by the general neuronal marker protein gene product 9.5. The presence of DbetaH and PNMT in the atrial specimens was verified using reverse transcriptase-polymerase chain reaction. Two types of catecholamine-handling intrinsic ganglion neurons were observed: small intensely fluorescent (SIF) cells and large-diameter neurons. SIF cells exhibited TH- and tryptophan hydroxylase-IR, but they were not positive for DbetaH. In contrast, large-diameter intrinsic TH-positive neurons, showing in majority also NPY-IR, displayed also DbetaH- and PNMT-IR, thus indicating the capacity for the synthesis of norepinephrine and epinephrine, respectively. In conclusion, the SIF cells are most probably dopaminergic and serotonergic neurons, whereas large-diameter intrinsic cells seem to represent a subpopulation of norepinephrine- and/or epinephrine-secreting neurons.
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Registered trials
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