ArticleOncogene2003
GATA-1 and c-myb crosstalk during red blood cell differentiation through GATA-1 binding sites in the c-myb promoter.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Genome-Wide Association Studies for 24 Hematological Traits in Production Pigs Before and After Weaning.Animal genetics · 2026Article
- GATA1 transcription factor targets the gene expression of B19 virus in HEK293 cell line.Annals of medicine and surgery (2012) · 2024Article
- MYB oncoproteins: emerging players and potential therapeutic targets in human cancer.Oncogenesis · 2021Review
- Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance.Biomarker research · 2020Review
- Polymorphisms in theCanine medicine and genetics · 2020Article
- Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils.Cell reports · 2018Article
- Review
- A new computational method to predict transcriptional activity of a DNA sequence from diverse datasets of massively parallel reporter assays.Nucleic acids research · 2017Article
- Article
- The development and maintenance of resident macrophages.Nature immunology · 2016Review
- p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses.Molecular & cellular proteomics : MCP · 2015Article
- Dynamics of GATA1 binding and expression response in a GATA1-induced erythroid differentiation system.Genomics data · 2015Article
- Kit transduced signals counteract erythroid maturation by MAPK-dependent modulation of erythropoietin signaling and apoptosis induction in mouse fetal liver.Cell death and differentiation · 2015Article
- Origins of the Vertebrate Erythro/Megakaryocytic System.BioMed research international · 2015Review
- Transcriptional mechanisms underlying hemoglobin synthesis.Cold Spring Harbor perspectives in medicine · 2013Review
- Article
- α-1,6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells.The Journal of biological chemistry · 2013Article
- Eafs control erythroid cell fate by regulating c-myb expression through Wnt signaling.PloS one · 2013Article
- MicroRNA miR-150 is involved in Vα14 invariant NKT cell development and function.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The role of meis1 in primitive and definitive hematopoiesis during zebrafish development.Haematologica · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GATA-1 and c-Myb transcription factors represent key regulators of red blood cell development. GATA-1 is upregulated and c-myb proto-oncogene expression is downregulated when red cell progenitors differentiate into erythrocytes. Here we have employed a culture system, that faithfully recapitulates red blood cell differentiation in vitro, to follow the kinetics of GATA-1 and c-myb expression. We show that c-myb proto-oncogene expression is high in progenitors and effectively downregulated at the time when nuclear GATA-1 accumulates and cells differentiate into erythrocytes. Additionally, we identified two GATA-1 binding sites within the c-myb promoter and demonstrate that GATA-1 protein binds to these sites in vitro. Furthermore, GATA-1 represses c-myb expression through one of the GATA-1 binding sites in transient transfection experiments and this requires FOG-1. Thus, our study provides evidence for a direct molecular link between GATA-1 activity and c-myb proto-oncogene expression during terminal red cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.