ArticleProceedings of the National Academy of Sciences of the United States of America2003
Inhibition of calcineurin facilitates the induction of memory for sensitization in Aplysia: requirement of mitogen-activated protein kinase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Calcineurin/NFAT inhibitors maintain cognition in a preclinical prevention study in an aging canine model of Alzheimer disease.Neurobiology of aging · 2025Article
- Precise timing of ERK phosphorylation/dephosphorylation determines the outcome of trial repetition during long-term memory formation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Possible novel features of synaptic regulation during long-term facilitation inLearning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Spinal protein phosphatase 1 constrains respiratory plasticity after sustained hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Calcineurin/P-ERK/Egr-1 Pathway is Involved in Fear Memory Impairment after Isoflurane Exposure in Mice.Scientific reports · 2017Article
- Role of protein synthesis and DNA methylation in the consolidation and maintenance of long-term memory ineLife · 2017Article
- Transforming growth factor β recruits persistent MAPK signaling to regulate long-term memory consolidation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model.Neural plasticity · 2016Article
- Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity.Military Medical Research · 2016Review
- Synaptic generation of an intracellular retrograde signal requires activation of the tyrosine kinase and mitogen-activated protein kinase signaling cascades in Aplysia.Neurobiology of learning and memory · 2015Article
- Reduced Incidence of Dementia in Solid Organ Transplant Patients Treated with Calcineurin Inhibitors.Journal of Alzheimer's disease : JAD · 2015Article
- Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia.eLife · 2014Article
- Doxorubicin attenuates serotonin-induced long-term synaptic facilitation by phosphorylation of p38 mitogen-activated protein kinase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- In vitro extinction learning in Hermissenda: involvement of conditioned inhibition molecules.Frontiers in behavioral neuroscience · 2014Article
- Pattern and predictability in memory formation: from molecular mechanisms to clinical relevance.Neurobiology of learning and memory · 2013Review
- Protein phosphatase-dependent circadian regulation of intermediate-term associative memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB.Molecular brain · 2012Review
- Massed training-induced intermediate-term operant memory in aplysia requires protein synthesis and multiple persistent kinase cascades.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Small G proteins exhibit pattern sensitivity in MAPK activation during the induction of memory and synaptic facilitation in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The induction of both synaptic plasticity and memory is thought to depend on the balance between opposing molecular regulatory factors, such as protein kinases and phosphatases. Here we show that inhibition of protein phosphatase 2B (calcineurin, CaN) facilitates the induction of intermediate-term memory (ITM) and long-term memory (LTM) for tail shock-induced sensitization in Aplysia without any effect on short-term memory. To identify the molecular cascade underlying the improvement of memory by inhibition of CaN, we examined the role of extracellular signal-regulated kinase 1/2/mitogen-activated protein kinase (MAPK). Molecular experiments revealed that one pulse of serotonin, which by itself does not activate MAPK, leads to significant MAPK activation in the sensory neurons of the pleural ganglia when CaN is inhibited. Extending these observations, behavioral experiments showed that the facilitated induction of ITM and LTM produced by CaN inhibition depends on MAPK activity. These results demonstrate: (i) that CaN acts as an inhibitory constraint in the formation of long-lasting phases of memory, and (ii) that facilitated induction of ITM and LTM by CaN inhibition requires MAPK activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.