ArticleGenes & development2003
XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Multilevel transcriptional regulation of embryonic sex determination and dosage compensation by the X-signal element sex-1.Genetics · 2026Article
- Origins of Self-Fertility in ThreeBiology · 2026Review
- Multi-level transcriptional regulation of embryonic sex determination and dosage compensation by the X-signal elementbioRxiv : the preprint server for biology · 2024Article
- Rapid chromosome evolution and acquisition of thermosensitive stochastic sex determination in nematode androdioecious hermaphrodites.Nature communications · 2024Article
- XOL-1 regulates developmental timing by modulating the H3K9 landscape in C. elegans early embryos.PLoS genetics · 2024Article
- Evolution of sex determination in crustaceans.Marine life science & technology · 2023Review
- The X chromosome in C. elegans sex determination and dosage compensation.Current opinion in genetics & development · 2022Review
- Review
- Transcriptional profiles in Strongyloides stercoralis males reveal deviations from the Caenorhabditis sex determination model.Scientific reports · 2021Article
- Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determineeLife · 2020Article
- Article
- Molecular modeling and simulation study of homoserine kinase as an effective leishmanial drug target.Journal of molecular modeling · 2020Article
- Males, Outcrossing, and Sexual Selection inGenetics · 2019Review
- Sex and death: from cell fate specification to dynamic control of X-chromosome structure and gene expression.Molecular biology of the cell · 2018Article
- From "the Worm" to "the Worms" and Back Again: The Evolutionary Developmental Biology of Nematodes.Genetics · 2018Review
- A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans.Developmental cell · 2018Article
- Analysis of the global transcriptome of longan (Dimocarpus longan Lour.) embryogenic callus using Illumina paired-end sequencing.BMC genomics · 2013Article
- Molecular antagonism between X-chromosome and autosome signals determines nematode sex.Genes & development · 2013Article
- Targeting X chromosomes for repression.Current opinion in genetics & development · 2010Review
- The worm solution: a chromosome-full of condensin helps gene expression go down.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In Caenorhabditis elegans, an X chromosome-counting mechanism specifies sexual fate. Specific genes termed X-signal elements, which are present on the X chromosome, act in a concerted dose-dependent fashion to regulate levels of the developmental switch gene xol-1. In turn, xol-1 levels determine sexual fate and the activation state of the dosage compensation mechanism. The crystal structure of the XOL-1 protein at 1.55 A resolution unexpectedly reveals that xol-1 encodes a GHMP kinase family member, despite sequence identity of 10% or less. Because GHMP kinases, thus far, have only been characterized as small molecule kinases involved in metabolic pathways, for example, amino acid and cholesterol synthesis, XOL-1 is the first member that controls nonmetabolic processes. Biochemical investigations demonstrated that XOL-1 does not bind ATP under standard conditions, suggesting that XOL-1 acts by a mechanism distinct from that of other GHMP kinases. In addition, we have cloned a XOL-1 ortholog from Caenorhabditis briggsae, a related nematode that diverged from C. elegans approximately 50-100 million years ago. These findings demonstrate an unanticipated role for GHMP kinase family members as mediators of sexual differentiation and dosage compensation and, possibly, other aspects of differentiation and development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.