ArticleGenes & development2003
Genomic instability and endoreduplication triggered by RAD17 deletion.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- Multiple roles of replication factor C family in pan‑cancer (Review).Oncology reports · 2025Review
- DNA Damage and Replication Stress Checkpoints.Annual review of biochemistry · 2025Review
- Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress.Scientific reports · 2021Article
- The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Article
- Eukaryotic clamp loaders and unloaders in the maintenance of genome stability.Experimental & molecular medicine · 2020Review
- OsRAD17 Is Required for Meiotic Double-Strand Break Repair and Plays a Redundant Role With OsZIP4 in Synaptonemal Complex Assembly.Frontiers in plant science · 2018Article
- TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response.EMBO reports · 2017Article
- Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi.Nucleic acids research · 2015Article
- Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.Science (New York, N.Y.) · 2015Article
- Slug is temporally regulated by cyclin E in cell cycle and controls genome stability.Oncogene · 2015Article
- Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.The EMBO journal · 2014Article
- Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment.The Journal of biological chemistry · 2013Article
- INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.The EMBO journal · 2010Article
- Article
- Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.Human molecular genetics · 2010Article
- Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.Cancer cell · 2009Article
- Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins.Oncogene · 2008Article
- Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability.The Journal of cell biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Cell cycle checkpoints are critical for genomic stability. Rad17, a component of the checkpoint clamp loader complex (Rad17/Rfc2-5), is required for the response to DNA damage and replication stress. To explore the role of Rad17 in the maintenance of genomic integrity, we established somatic conditional alleles of RAD17 in human cells. We find that RAD17 is not only important for the Atr-mediated checkpoint but is also essential for cell viability. Cells lacking RAD17 exhibited acute chromosomal aberrations and underwent endoreduplication at a high rate. Therefore, RAD17 links the checkpoint to ploidy control and is essential for the maintenance of chromosomal stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.