ReviewImmunogenetics2003
Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor structure and function.
Review in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy.Journal of clinical medicine · 2020Article
- Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome.Scientific reports · 2018Article
- Inflammatory cytokines in pediatric obstructive sleep apnea.Medicine · 2016Observational
- Variations in IL-23 and IL-25 receptor gene structure, sequence and expression associated with the two disease forms of sheep paratuberculosis.Veterinary research · 2016Article
- The introduction of RNA-DNA differences underlies interindividual variation in the human IL12RB1 mRNA repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- IL12Rβ1ΔTM is a secreted product of il12rb1 that promotes control of extrapulmonary tuberculosis.Infection and immunity · 2015Article
- IL-12Rβ1 deficiency: mutation update and description of the IL12RB1 variation database.Human mutation · 2013Review
- Cytokines in radiobiological responses: a review.Radiation research · 2012Review
- Article
- Interleukin-23 as a potential therapeutic target for rheumatoid arthritis.Molecular and cellular biochemistry · 2012Review
- Review
- Rapid multiplex high resolution melting method to analyze inflammatory related SNPs in preterm birth.BMC research notes · 2012Article
- Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assays.Clinical and vaccine immunology : CVI · 2010Article
- SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine.Immunogenetics · 2010Article
- Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration.The Journal of experimental medicine · 2010Article
- Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing.Immunity · 2009Article
- Identification and characterization of multiple splice forms of the human interleukin-23 receptor alpha chain in mitogen-activated leukocytes.Genes and immunity · 2008Article
- A novel insertion variant of the human IL-23 receptor-alpha chain transcript.Genes and immunity · 2008Article
- Human leukocyte antigen and cytokine receptor gene polymorphisms associated with heterogeneous immune responses to mumps viral vaccine.Pediatrics · 2008Article
- Intranasal interleukin-12 treatment promotes antimicrobial clearance and survival in pulmonary Francisella tularensis subsp. novicida infection.Antimicrobial agents and chemotherapy · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-mediated immunity (CMI) plays an essential role in human host defense against intracellular bacteria. Type-1 cytokines, particularly gamma interferon (IFN-gamma), interleukin-12 (IL-12), and IL-23, the major cytokines that regulate IFN-gamma production, are essential in CMI. This is illustrated by patients with unusual severe infections caused by poorly pathogenic mycobacteria and Salmonella species, in whom genetic deficiencies have been identified in several key genes in the type-1 cytokine pathway, including IL12RB1, the gene encoding the beta1 chain of the IL-12 and IL-23 receptors. Several mutations in IL12RB1 with deleterious effects on human IL-12R function have been identified, including nonsense and missense mutations. In addition, a number of coding IL12RB1 polymorphisms have been reported. In order to gain more insight into the effect that IL12RB1 mutations and genetic variations can have on IL-12Rbeta1 function, three approaches have been followed. First, we determined the degree of conservation at the variant amino acid positions in IL-12Rbeta1 between different species, using known deleterious mutations, known variations in IL-12Rbeta1, as well as novel coding variations that we have identified at position S74R and R156H. Second, we analyzed the potential impact of these amino acid variations on the three-dimensional structure of the IL-12Rbeta1 protein. Third, we analyzed the putative functions of different IL-12Rbeta1 domains, partly based on their homology with gp130, and analyzed the possible effects of the above amino acid variations on the function of these domains. Based on these analyses, we propose an integrated model of IL-12Rbeta1 structure and function. This significantly enhances our molecular understanding of the human IL-12 and IL-23 systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.