ArticleBritish journal of cancer2003
Reactivity to human papillomavirus type 16 L1 virus-like particles in sera from patients with genital cancer and patients with carcinomas at five different extragenital sites.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- HPV prevalence in esophageal cancer: an updated systematic review and meta-analysis.Frontiers in microbiology · 2026Pooled it
- Associations Between Gastric Cancer Risk and Virus Infection Other Than Epstein-Barr Virus: A Systematic Review and Meta-analysis Based on Epidemiological Studies.Clinical and translational gastroenterology · 2020Pooled it
- Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis.BMC cancer · 2014Pooled it
- Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis.Epidemiology and infection · 2014Pooled it
- InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers.Journal of the National Cancer Institute · 2012Pooled it
- Penile cancer: epidemiology, pathogenesis and prevention.World journal of urology · 2009Pooled it
- Human papillomavirus infection and gastric cancer risk: A meta-epidemiological review.World journal of virology · 2021Review
- Article
- Molecular and serologic markers of HPV 16 infection are associated with local recurrence in patients with oral cavity squamous cell carcinoma.Oncotarget · 2017Article
- Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases.OncoTargets and therapy · 2016Article
- Article
- HPV frequency in penile carcinoma of Mexican patients: important contribution of HPV16 European variant.International journal of clinical and experimental pathology · 2013Article
- Human papillomavirus in upper digestive tract tumors from three countries.World journal of gastroenterology · 2011Article
- Genital HPV infection and related lesions in men.Preventive medicine · 2011Review
- Human papillomavirus seropositivity synergizes with MDM2 variants to increase the risk of oral squamous cell carcinoma.Cancer research · 2010Article
- Role of human papillomavirus and cell cycle-related variants in squamous cell carcinoma of the oropharynx.Journal of biomedical research · 2010Article
- Environmental causes of esophageal cancer.Gastroenterology clinics of North America · 2009Review
- The relationship between anti-HPV-16 IgG seropositivity and cancer of the cervix, anogenital organs, oral cavity and pharynx, oesophagus and prostate in a black South African population.Infectious agents and cancer · 2007Article
- More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population.BMC infectious diseases · 2006Article
- The role of human papillomavirus in squamous carcinoma of the head and neck.Current oncology reports · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A retrospective seroepidemiologic study was performed to examine the association between human papillomaviruses (HPV) 16 infection and carcinomas of the oropharynx, the oesophagus, penis and vagina. Sera were selected from the serum bank from the Antoni van Leeuwenhoek Hospital (Netherlands Cancer Institute) and the Slotervaart Hospital in Amsterdam, the Netherlands. Presence of HPV 16 specific antibody was assessed using HPV 16 L1 capsids. Sera positive for HPV 16 capsid antibody were further tested for antibody against HPV 16 E7 peptides. Prevalence of antibody against HPV 16 L1 capsids among both the negative control group without cancer and the negative control group with gastric cancer was 18%, while seroprevalence among the control group of patients with HPV-associated cervical squamous cell carcinoma was 47% (P<0.001). Among the patients with penile squamous cell carcinoma seroprevalence was 38% (P<0.001), among patients with oropharyngeal carcinoma 33% (P=0.04) and among patients with oesophageal squamous cell carcinoma 14% (P=0.7). The serological evidence for association between HPV 16 infection and both oropharyngeal carcinoma and penile carcinoma was established. The conclusion that no association was found between the presence of antibody against HPV 16 L1 capsids and oesophageal squamous cell carcinoma was in accordance with results of other studies carried out in the Netherlands using HPV DNA technology. In the subjects with HPV 16 L1 capsid antibody, no association was found between the antibody against HPV 16 E7 and clinical outcome.
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