ArticleBritish journal of cancer2003
Tyrosine-kinase expression profiles in human gastric cancer cell lines and their modulations with retinoic acids.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Proteomic quantification of receptor tyrosine kinases involved in the development and progression of colorectal cancer liver metastasis.Frontiers in oncology · 2023Article
- Proteomics of colorectal cancer liver metastasis: A quantitative focus on drug elimination and pharmacodynamics effects.British journal of clinical pharmacology · 2022Article
- Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers.Expert reviews in molecular medicine · 2014Review
- Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival.British journal of cancer · 2009Article
- Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers.World journal of gastroenterology · 2008Article
- Wobble splicing reveals the role of the branch point sequence-to-NAGNAG region in 3' tandem splice site selection.Molecular and cellular biology · 2007Article
- Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival.BMC cancer · 2006Article
- EPHA2/EFNA1 expression in human gastric cancer.Cancer science · 2005Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many protein tyrosine kinases are key regulators involved in cellular growth, differentiation, development, apoptosis and signal transduction pathways. Obtaining a comprehensive tyrosine-kinase expression profile in tumour cells is essential to learning more about their oncogenic potentials and responses to various chemotherapeutic reagents - such as retinoic acid, which has been shown to suppress the growth of gastric cancer cells and modulate gene expression. Expression of tyrosine kinases in retionic acid-treated cancer cells was investigated by reverse trancriptase-polymerase chain reaction (RT-PCR) and a novel restriction analysis of gene expression (RAGE) display technique. We first established comprehensive tyrosine-kinase profiles in different human gastric cancer cell lines. In cells treated with 9-cis-retinoic acid or all-trans-retinoic acid, we found that two PTKs (Eph and Hek5) appeared to be upregulated. In the present study, we demonstrate an efficient and simple RAGE approach for examining tyrosine kinases' expression in tumour cells and their alterations following drug treatments.
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