ArticleProceedings of the National Academy of Sciences of the United States of America2003
IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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Who cites it
59 citing papers in PubMed, 155 citations in OpenAlex.
- Transpresentation of interleukin 15 by stromal cell subsets regulates immune cell homeostasis.Frontiers in immunology · 2025Article
- Gut microbiota influence acute pancreatitis through inflammatory proteins: a Mendelian randomization analysis.Frontiers in cellular and infection microbiology · 2024Article
- GD2-targeting therapy: a comparative analysis of approaches and promising directions.Frontiers in immunology · 2024Review
- Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation.Frontiers in immunology · 2022Article
- Homeostasis of Naive and Memory T Lymphocytes.Cold Spring Harbor perspectives in biology · 2021Review
- Heterodimeric IL-15 in Cancer Immunotherapy.Cancers · 2021Review
- Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer.The Journal of experimental medicine · 2020Review
- The Transcription Factor Runx2 Is Required for Long-Term Persistence of Antiviral CD8ImmunoHorizons · 2018Article
- Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo.Science translational medicine · 2018Article
- IL-2 and Beyond in Cancer Immunotherapy.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2018Review
- The potential and promise of IL-15 in immuno-oncogenic therapies.Immunology letters · 2017Review
- IL-15-deficient mice develop enhanced allergic responses to airway allergen exposure.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction.Nature reviews. Immunology · 2015Review
- Chitosan hydrogel vaccine generates protective CD8 T cell memory against mouse melanoma.Immunology and cell biology · 2015Article
- Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Regulation of mouse NK cell development and function by cytokines.Frontiers in immunology · 2013Review
- Transcriptional regulation of IL-15 expression during hematopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells.American journal of respiratory and critical care medicine · 2013Article
- Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The generation and maintenance of immunological memory requires the activation, expansion, and persistent proliferation of antigen-specific T cells. Recent work suggests that IL-15 may be important for this process. Surprisingly, we now find that expression of the high-affinity receptor for IL-15, IL-15R alpha, on T cells is dispensable for the generation or maintenance of memory CD8(+) T cells. By contrast, IL-15R alpha expression on cells other than T cells is absolutely critical for this function. These findings may be related to IL-15R alpha's ability to present IL-15 in trans to low-affinity IL-15R beta gamma(c) receptors on memory CD8(+) T cells. These unexpected results provide insights into how IL-15R alpha supports memory CD8(+) T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.