ArticleProceedings of the National Academy of Sciences of the United States of America2003
Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 80 citations in OpenAlex.
- Article
- Dynamic allelic expression in mouse mammary glands across the adult developmental cycle.Nucleic acids research · 2025Article
- Creatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth.Cell metabolism · 2024Article
- miRNA expression profiles of peripheral white blood cells from beef heifers with varying reproductive potential.Frontiers in genetics · 2023Article
- Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy.Nature cardiovascular research · 2022Article
- Review
- Machine learning discriminates a movement disorder in a zebrafish model of Parkinson's disease.Disease models & mechanisms · 2020Article
- Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Identification of Pathways Associated with Placental Adaptation to Maternal Nutrient Restriction in Sheep.Genes · 2020Article
- Large-Scale Differential Gene Expression Transcriptomic Analysis Identifies a Metabolic Signature Shared by All Cancer Cells.Biomolecules · 2020Article
- Modeling allele-specific expression at the gene and SNP levels simultaneously by a Bayesian logistic mixed regression model.BMC bioinformatics · 2019Article
- Evolutionary expression differences of creatine synthesis-related genes: Implications for skeletal muscle metabolism in fish.Scientific reports · 2019Article
- Maternal Choline Supplementation during Normal Murine Pregnancy Alters the Placental Epigenome: Results of an Exploratory Study.Nutrients · 2018Article
- RNA-Seq reveals 10 novel promising candidate genes affecting milk protein concentration in the Chinese Holstein population.Scientific reports · 2016Article
- A GWAS assessment of the contribution of genomic imprinting to the variation of body mass index in mice.BMC genomics · 2015Article
- Creatine metabolism differs between mammals and rainbow trout (Oncorhynchus mykiss).SpringerPlus · 2014Article
- Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate.Journal of human genetics · 2013Observational
- Expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 and the methylation patterns at the KvDMR1 and H19/IGF2 imprinting control regions is conserved between human and bovine.Journal of biomedical science · 2012Article
- A survey of tissue-specific genomic imprinting in mammals.Molecular genetics and genomics : MGG · 2012Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To increase our understanding of imprinting and epigenetic gene regulation, we undertook a search for new imprinted genes. We identified Gatm, a gene that encodes l-arginine:glycine amidinotransferase, which catalyzes the rate-limiting step in the synthesis of creatine. In mouse, Gatm is expressed during development and is imprinted in the placenta and yolk sac, but not in embryonic tissues. The Gatm gene maps to mouse chromosome 2 in a region not previously shown to contain imprinted genes. To determine whether Gatm is located in a cluster of imprinted genes, we investigated the expression pattern of genes located near Gatm: Duox1-2, Slc28a2, Slc30a4 and a transcript corresponding to LOC214616. We found no evidence that any of these genes is imprinted in placenta. We show that a CpG island associated with Gatm is unmethylated, as is a large CpG island associated with a neighboring gene. This genomic screen for novel imprinted genes has elucidated a new connection between imprinting and creatine metabolism during embryonic development in mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.