ArticleGenome research2003
The first-generation whole-genome radiation hybrid map in the horse identifies conserved segments in human and mouse genomes.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 159 citations in OpenAlex.
- Alignment-free method for DNA sequence clustering using Fuzzy integral similarity.Scientific reports · 2019Article
- Construction of two whole genome radiation hybrid panels for dromedary (Camelus dromedarius): 5000Scientific reports · 2018Article
- Applied equine genetics.Equine veterinary journal · 2014Review
- Mapping and genotypic analysis of the NK-lysin gene in chicken.Genetics, selection, evolution : GSE · 2014Article
- Article
- IgA in the horse: cloning of equine polymeric Ig receptor and J chain and characterization of recombinant forms of equine IgA.Mucosal immunology · 2010Article
- Equine clinical genomics: A clinician's primer.Equine veterinary journal · 2010Review
- Whole-genome scan identifies quantitative trait loci for chronic pastern dermatitis in German draft horses.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- A first generation whole genome RH map of the river buffalo with comparison to domestic cattle.BMC genomics · 2008Article
- Equine Multiple Congenital Ocular Anomalies maps to a 4.9 megabase interval on horse chromosome 6.BMC genetics · 2008Article
- The horse genome derby: racing from map to whole genome sequence.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
- Multidirectional cross-species painting illuminates the history of karyotypic evolution in Perissodactyla.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- A 4,103 marker integrated physical and comparative map of the horse genome.Cytogenetic and genome research · 2008Article
- Genome-wide search for markers associated with osteochondrosis in Hanoverian warmblood horses.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Whole-genome linkage disequilibrium screening for complex traits in horses.Molecular genetics and genomics : MGG · 2007Article
- Genome-wide search for microsatellite markers associated with radiologic alterations in the navicular bone of Hanoverian warmblood horses.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Establishment of high-resolution FISH mapping system and its application for molecular cytogenetic characterization of chromosomes in newt, Cynops pyrrhogaster (Urodela, Amphibia).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Article
- Article
- What could Dr Finlay and Mr Herriot learn from each other?BMJ (Clinical research ed.) · 2005Article
- A high-resolution physical map of equine homologs of HSA19 shows divergent evolution compared with other mammals.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A first-generation radiation hybrid (RH) map of the equine (Equus caballus) genome was assembled using 92 horse x hamster hybrid cell lines and 730 equine markers. The map is the first comprehensive framework map of the horse that (1) incorporates type I as well as type II markers, (2) integrates synteny, cytogenetic, and meiotic maps into a consensus map, and (3) provides the most detailed genome-wide information to date on the organization and comparative status of the equine genome. The 730 loci (258 type I and 472 type II) included in the final map are clustered in 101 RH groups distributed over all equine autosomes and the X chromosome. The overall marker retention frequency in the panel is approximately 21%, and the possibility of adding any new marker to the map is approximately 90%. On average, the mapped markers are distributed every 19 cR (4 Mb) of the equine genome--a significant improvement in resolution over previous maps. With 69 new FISH assignments, a total of 253 cytogenetically mapped loci physically anchor the RH map to various chromosomal segments. Synteny assignments of 39 gene loci complemented the RH mapping of 27 genes. The results added 12 new loci to the horse gene map. Lastly, comparison of the assembly of 447 equine genes (256 linearly ordered RH-mapped and additional 191 FISH-mapped) with the location of draft sequences of their human and mouse orthologs provides the most extensive horse-human and horse-mouse comparative map to date. We expect that the foundation established through this map will significantly facilitate rapid targeted expansion of the horse gene map and consequently, mapping and positional cloning of genes governing traits significant to the equine industry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.