ArticleGenome research2003
Species-specific class I gene expansions formed the telomeric 1 mb of the mouse major histocompatibility complex.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C.The Journal of biological chemistry · 2016Article
- Structure and function of the non-classical major histocompatibility complex molecule MR1.Immunogenetics · 2016Review
- Restricting nonclassical MHC genes coevolve with TRAV genes used by innate-like T cells in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The MHC class I genes of zebrafish.Developmental and comparative immunology · 2014Review
- Pronuclear injection-based mouse targeted transgenesis for reproducible and highly efficient transgene expression.Nucleic acids research · 2010Article
- A complete DNA sequence map of the ovine major histocompatibility complex.BMC genomics · 2010Article
- GABAB receptor constituents revealed by tandem affinity purification from transgenic mice.The Journal of biological chemistry · 2010Article
- Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6.BMC genomics · 2008Article
- Structure and expression of MHC class Ib genes of the central M region in rat and mouse: M4, M5, and M6.Immunogenetics · 2008Article
- Unprecedented intraspecific diversity of the MHC class I region of a teleost medaka, Oryzias latipes.Immunogenetics · 2005Article
- Comparative genomics of major histocompatibility complexes.Immunogenetics · 2005Review
- The feline major histocompatibility complex is rearranged by an inversion with a breakpoint in the distal class I region.Immunogenetics · 2005Article
- Active MHC class Ib genes in rat are pseudogenes in the mouse.Immunogenetics · 2004Article
- The genomic sequence and comparative analysis of the rat major histocompatibility complex.Genome research · 2004Article
- Comparative genome organization of human, murine, and feline MHC class II region.Genome research · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
We have determined the complete sequence of 951,695 bp from the class I region of H2, the mouse major histocompatibility complex (Mhc) from strain 129/Sv (haplotype bc). The sequence contains 26 genes. The sequence spans from the last 50 kb of the H2-T region, including 2 class I genes and 3 class I pseudogenes, and includes the H2-M region up to Gabbr1. A 500-kb stretch of the H2-M region contains 9 class I genes and 4 pseudogenes, which fall into two subfamilies, M1 and M10, distinct from other mouse class I genes. This M1/M10 class I gene-cluster is separated from the centromeric H2-T and the telomeric H2-M4, -5 and -6 class I genes by "nonclass I genes". Comparison with the corresponding 853-kb region of the human Mhc, which includes the HLA-A region, shows a mosaic of conserved regions of orthologous nonclass I genes separated by regions of species-specific expansion of paralogous Mhc class I genes. The analysis of this mosaic structure illuminates the dynamic evolution of the Mhc class I region among mammals and provides evidence for the framework hypothesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.