ArticleJournal of bacteriology2003
Evolutionary relationships among strains of Mycobacterium tuberculosis with few copies of IS6110.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Unexpected diversity of CRISPR unveils some evolutionary patterns of repeated sequences in Mycobacterium tuberculosis.BMC genomics · 2020Article
- Diverse Molecular Genotypes of Mycobacterium tuberculosis Complex Isolates Circulating in the Free State, South Africa.International journal of microbiology · 2016Article
- Analysis of IS6110 insertion sites provide a glimpse into genome evolution of Mycobacterium tuberculosis.Scientific reports · 2015Article
- Molecular diversity of Mycobacterium tuberculosis strains indifferent provinces of Iran.Iranian journal of microbiology · 2013Article
- Mapping IS6110 in high-copy number Mycobacterium tuberculosis strains shows specific insertion points in the Beijing genotype.BMC genomics · 2013Article
- Spoligotypes of Mycobacterium tuberculosis from different Provinces of China.Journal of clinical microbiology · 2010Article
- Characterization of Mycobacterium tuberculosis complex isolated from iranian and afghani patients by spoligotyping method.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2009Article
- Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family.Journal of clinical microbiology · 2008Article
- Large sequence polymorphisms classify Mycobacterium tuberculosis strains with ancestral spoligotyping patterns.Journal of clinical microbiology · 2007Article
- First insight into the population structure of Mycobacterium tuberculosis in Saudi Arabia.Journal of clinical microbiology · 2007Article
- Predominance of ancestral lineages of Mycobacterium tuberculosis in India.Emerging infectious diseases · 2006Article
- The emergence of Beijing family genotypes of Mycobacterium tuberculosis and low-level protection by bacille Calmette-Guérin (BCG) vaccines: is there a link?Clinical and experimental immunology · 2006Review
- Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology.BMC microbiology · 2006Article
- Can 15-locus mycobacterial interspersed repetitive unit-variable-number tandem repeat analysis provide insight into the evolution of Mycobacterium tuberculosis?Applied and environmental microbiology · 2005Article
- Natural transposon mutagenesis of clinical isolates of Mycobacterium tuberculosis: how many genes does a pathogen need?Journal of bacteriology · 2005Article
- Long-term molecular analysis of tuberculosis strains in alabama, a state characterized by a largely indigenous, low-risk population.Journal of clinical microbiology · 2005Article
- Clonal expansion of a globally disseminated lineage of Mycobacterium tuberculosis with low IS6110 copy numbers.Journal of clinical microbiology · 2004Article
- Characterization of ancestral Mycobacterium tuberculosis by multiple genetic markers and proposal of genotyping strategy.Journal of clinical microbiology · 2004Article
- Correlation of virulence, lung pathology, bacterial load and delayed type hypersensitivity responses after infection with different Mycobacterium tuberculosis genotypes in a BALB/c mouse model.Clinical and experimental immunology · 2004Article
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Authors and funding
15 authors.
Funding
Abstract
Molecular typing of Mycobacterium tuberculosis by using IS6110 shows low discrimination when there are fewer than five copies of the insertion sequence. Using a collection of such isolates from a study of the epidemiology of tuberculosis in London, we have shown a substantial degree of congruence between IS6110 patterns and both spoligotype and PGRS type. This indicates that the IS6110 types mainly represent distinct families of strains rather than arising through the convergent insertion of IS6110 into favored positions. This is supported by identification of the genomic sites of the insertion of IS6110 in these strains. The combined data enable identification of the putative evolutionary relationships of these strains, comprising three lineages broadly associated with patients born in South Asia (India and Pakistan), Africa, and Europe, respectively. These lineages appear to be quite distinct from M. tuberculosis isolates with multiple copies of IS6110.
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