ArticleGenes & development2003
In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Probing the conserved roles of cut in the development and function of optically different insect compound eyes.Frontiers in cell and developmental biology · 2023Article
- T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development.Frontiers in cell and developmental biology · 2021Review
- The Leukemic Fly: Promises and Challenges.Cells · 2020Review
- Evidence That Runt Acts as a Counter-Repressor of Groucho DuringG3 (Bethesda, Md.) · 2020Article
- Tle corepressors are differentially partitioned to instruct CD8The Journal of experimental medicine · 2018Article
- The Role of Runx1 in Embryonic Blood Cell Formation.Advances in experimental medicine and biology · 2017Review
- Conditional knockout of retinal determination genes in differentiating cells in Drosophila.The FEBS journal · 2016Article
- Origins of context-dependent gene repression by capicua.PLoS genetics · 2015Article
- Wnt-mediated repression via bipartite DNA recognition by TCF in the Drosophila hematopoietic system.PLoS genetics · 2014Article
- Deadpan contributes to the robustness of the notch response.PloS one · 2013Article
- Tyrosyl phosphorylation toggles a Runx1 switch.Genes & development · 2012Article
- The lens in focus: a comparison of lens development in Drosophila and vertebrates.Molecular genetics and genomics : MGG · 2011Review
- Misregulation of the LOB domain gene DDA1 suggests possible functions in auxin signalling and photomorphogenesis.Journal of experimental botany · 2011Article
- Article
- Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives.Development (Cambridge, England) · 2010Review
- Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc.BMC developmental biology · 2009Article
- The robotic mouse: understanding the role of AF4, a cofactor of transcriptional elongation and chromatin remodelling, in purkinje cell function.Cerebellum (London, England) · 2009Review
- Is Runx a linchpin for developmental signaling in metazoans?Journal of cellular biochemistry · 2009Article
- The evolution of Runx genes II. The C-terminal Groucho recruitment motif is present in both eumetazoans and homoscleromorphs but absent in a haplosclerid demosponge.BMC research notes · 2009Article
- The Groucho/TLE/Grg family of transcriptional co-repressors.Genome biology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Runx proteins have been implicated in acute myeloid leukemia, cleidocranial dysplasia, and stomach cancer. These proteins control key developmental processes in which they function as both transcriptional activators and repressors. How these opposing regulatory modes can be accomplished in the in vivo context of a cell has not been clear. In this study we use the developing cone cell in the Drosophila visual system to elucidate the mechanism of positive and negative regulation by the Runx protein Lozenge (Lz). We describe a regulatory circuit in which Lz causes transcriptional activation of the homeodomain protein Cut, which can then stabilize a Lz repressor complex in the same cell. Whether a gene is activated or repressed is determined by whether the Lz activator or the repressor complex binds to its upstream sequence. This study provides a mechanistic basis for the dual function of Runx proteins that is likely to be conserved in mammalian systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.