ArticleJournal of cancer research and clinical oncology2003
The alteration of PTEN tumor suppressor expression and its association with the histopathological features of human primary hepatocellular carcinoma.
Article in Journal of cancer research and clinical oncology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma.Liver research (Beijing, China) · 2021Article
- miR-3691-5p promotes hepatocellular carcinoma cell migration and invasion through activating PI3K/Akt signaling by targeting PTEN.OncoTargets and therapy · 2019Article
- Association of PTEN expression with liver function and inflammatory changes in patients with liver cancer after chemotherapy.Oncology letters · 2018Article
- Targeting interleukin-1 receptor-associated kinase 1 for human hepatocellular carcinoma.Journal of experimental & clinical cancer research : CR · 2016Article
- Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a.Antioxidants & redox signaling · 2013Article
- Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model.PloS one · 2011Article
- PTEN in liver diseases and cancer.World journal of gastroenterology · 2010Article
- Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice.World journal of gastroenterology · 2009Article
- PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma.Cancer research · 2008Article
- Tumor suppressor and hepatocellular carcinoma.World journal of gastroenterology · 2008Review
- Effects and mechanisms of silibinin on human hepatoma cell lines.World journal of gastroenterology · 2007Article
- MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.Gastroenterology · 2007Article
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough deletions or inactivating mutations of the tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) are involved in the development of a variety of tumors including glioblastoma, melanoma, prostate cancer, breast cancer, endometrial cancers etc., the role of PTEN expression in human primary hepatocellular carcinoma (HCC) has not yet been clarified. The aim of this study is to investigate the involvement of PTEN mRNA and protein expression in HCC.
methodsThe level of PTEN mRNA expression in HCC specimens was analyzed by Northern blot. PTEN poly-clonal antibody was raised by immunizing New Zealand white rabbit with (His)(6)-tagged PTEN fusion protein and characterized by Western blot. The level of PTEN protein expression was determined by immunohistochemistry. The significance of PTEN in HCC was analyzed by comparing its expression level with the clinicopathological parameters of HCC patients.
resultsFour transcripts of PTEN mRNA at 5.5 kb, 4.4 kb, 2.4 kb, and 1.8 kb were detected in most para-carcinoma liver tissues, and the expression level of PTEN mRNA in carcinoma liver tissues was found to decrease significantly. The poly-clonal antibody raised against histidine-tagged fusion PTEN protein showed specific immuno-reactivity to PTEN protein. Using the specific poly-clonal antibody prepared and characterized by ourselves, we found that PTEN protein was significantly down-regulated in HCC tissues compared with paired para-carcinoma tissues. The protein expression of PTEN is negatively associated with the pathological grading and presence of cancer thrombus of HCC.
conclusionsDown-regulation of PTEN expression may play an important role in the development of HCC and the level of PTEN expression may be a potential adjuvant parameter in forecasting the progression and prognosis of HCC patients.
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