ArticlePsychopharmacology2003
Reversal of haloperidol-induced orofacial dyskinesia by quercetin, a bioflavonoid.
Article in Psychopharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 18 citations in OpenAlex.
- Molecular and Behavioral Neuroprotective Effects of Clavulanic Acid and Crocin in Haloperidol-Induced Tardive Dyskinesia in Rats.Molecular neurobiology · 2025Article
- Oxidative stress and the antipsychotic-induced vacuous chewing movement model of tardive dyskinesia: evidence for antioxidant-based prevention strategies.Psychopharmacology · 2014Review
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3 authors at 1 institution in 1 country.
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Abstract
rationaleTardive dyskinesia is a serious neurological syndrome associate with long-term administration of neuroleptics to humans and experimental animals. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels. Quercetin is a bioflavonoid with strong antioxidant properties.
objectivesTo evaluate the effect of chronic quercetin treatment on haloperidol-induced orofacial dyskinesia.
methodsVacuous chewing movements (VCM) in rats, a widely accepted animal model of tardive dyskinesia was employed in the present study. VCM were induced in rats by daily administration of haloperidol (1.0 mg/kg) for a period of 21 days. Animals with established dyskinesia were given quercetin for a period of 4 weeks and behavioral scoring was recorded every week before administration of quercetin. Animals were killed after the last behavioral recordings and biochemical estimations were carried out.
resultsChronic haloperidol (1.0 mg/kg for 21 days) treatment significantly induced VCM and tongue protrusions in rats and quercetin (25-100 mg/kg for 4 weeks) significantly reversed haloperidol-induced VCM and tongue protrusions. Biochemical analysis revealed that chronic haloperidol treatment significantly induced lipid peroxidation, decreased glutathione (GSH), superoxide dismutase (SOD), and catalase levels in the brains of rats. Quercetin (25-100 mg/kg for 4 weeks) significantly reduced lipid peroxidation and restored GSH, SOD and catalase levels.
conclusionsThe results of the present study clearly indicate that quercetin has a protective role against haloperidol-induced orofacial dyskinesia. Consequently, the use of quercetin as a therapeutic agent for the treatment of tardive dyskinesia should be considered.
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