ArticleThorax2003
T cell cytokine profiles in childhood asthma.
Article in Thorax, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05570383 (Observation on the Efficacy of Sublingual Immunotherapy With Dust Mite Allergen for Perennial Allergic Rhinitis and the Mechanism of Action on ILCs With ILC1s and ILC2s and ILC3s), which is not on this map. Cited by 15 papers.
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Observation on the Efficacy of Sublingual Immunotherapy With Dust Mite Allergen for Perennial Allergic Rhinitis and the Mechanism of Action on ILCs With ILC1s and ILC2s and ILC3s
Who cites it
15 citing papers in PubMed, 64 citations in OpenAlex.
- Mouse Models of Asthma: Characteristics, Limitations and Future Perspectives on Clinical Translation.Advances in experimental medicine and biology · 2022Article
- The profile of leucocytes, CD3+, CD4+, and CD8+ T cells, and cytokine concentrations in peripheral blood of children with acute asthma exacerbation.The Journal of international medical research · 2017Article
- Pentraxin 3 deletion aggravates allergic inflammation through a TThe Journal of allergy and clinical immunology · 2017Article
- Pplase of Dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model.Scientific reports · 2017Article
- Delayed asthmatic response to allergen challenge and cytokines released by nonspecifically stimulated blood cells.ISRN inflammation · 2013Article
- Evaluation of cytotoxic and anti-inflammatory activities of extracts and lectins from Moringa oleifera seeds.PloS one · 2013Article
- Biomarkers of immunotoxicity for environmental and public health research.International journal of environmental research and public health · 2011Review
- Cytokine/anti-cytokine therapy - novel treatments for asthma?British journal of pharmacology · 2011Review
- Can bronchial asthma be classified based on the immunological status?Lung India : official organ of Indian Chest Society · 2011Article
- Anisakis pegreffii-induced airway hyperresponsiveness is mediated by gamma interferon in the absence of interleukin-4 receptor alpha responsiveness.Infection and immunity · 2010Article
- Ozone and allergen exposure during postnatal development alters the frequency and airway distribution of CD25+ cells in infant rhesus monkeys.Toxicology and applied pharmacology · 2009Article
- Early environmental exposures and intracellular Th1/Th2 cytokine profiles in 24-month-old children living in an agricultural area.Environmental health perspectives · 2006Article
- Staphylococcus aureus enterotoxins induce IL-8 secretion by human nasal epithelial cells.Respiratory research · 2006Article
- Inflammatory process of CD8+ CD28- T cells in induced sputum from asthmatic patients.Mediators of inflammation · 2005Article
- Parasites and the hygiene hypothesis: regulating the immune system?Clinical reviews in allergy & immunology · 2004Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn imbalance of T cell subsets in asthma with a predominance of Th2 type cells has been proposed. The aim of this study was simultaneously to detect surface markers and intracellular production of cytokines in T cells from the airways of children with and without asthma.
methodsBronchoalveolar lavage (BAL) fluid was obtained by wedging a suction catheter into the distal airway immediately before elective surgery. Cells were stimulated with phorbol 12-myristrate 13-acetate (PMA) and ionomycin and intracytoplasmic cytokine retention was achieved using monensin. The cells were stained with the relevant antibodies and analysed by flow cytometry.
resultsNo statistical difference was observed between children with atopic asthma, atopic non-asthmatic subjects, and normal controls in the percentage of CD3+ cells producing interleukin (IL)-2 or IL-4. Interferon (IFN)gamma+ T cells were, however, present in a much higher percentage than either IL-2 or IL-4 positive cells. The percentage of IFNgamma+ T cells was significantly increased in subjects with atopic asthma (median 71.3%, interquartile range (IQR) 65.1-82.2, n=13) compared with both atopic non-asthmatic subjects (51.9%, IQR 37.2-70.3, n=12), p<0.05 and normal controls (58.1%, IQR 36.1-66.1, n=23), p<0.01.
conclusionsThese findings indicate that IFNgamma producing T cells are more abundant in the airways of children with atopic asthma than in atopic non-asthmatic subjects and controls. The proinflammatory activities of IFNgamma may play an important role in the pathogenesis of childhood asthma and may suggest that asthma is not simply a Th2 driven response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.