ArticleBiophysical journal2003
Role of hyperpolarization-activated currents for the intrinsic dynamics of isolated retinal neurons.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Multimodal classification of neurons in the lateral septum.bioRxiv : the preprint server for biology · 2026Article
- Latent epigenetic programs in Müller glia contribute to stress and disease response in the retina.Developmental cell · 2025Article
- Review
- Localization of hyperpolarization-activated cyclic nucleotide-gated channels in the vertebrate retinas across species and their physiological roles.Frontiers in neuroanatomy · 2024Review
- Cell-cell interaction in the pathogenesis of inherited retinal diseases.Frontiers in cell and developmental biology · 2024Review
- Light responses of mammalian cones.Pflugers Archiv : European journal of physiology · 2021Review
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Nicotine-Mediated ADP to Spike Transition: Double Spiking in Septal Neurons.The Journal of membrane biology · 2016Article
- A computational study on the role of gap junctions and rod Ih conductance in the enhancement of the dynamic range of the retina.PloS one · 2009Article
- An oscillatory circuit underlying the detection of disruptions in temporally-periodic patterns.Network (Bristol, England) · 2009Article
- The h channel mediates location dependence and plasticity of intrinsic phase response in rat hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- High-pass filtering of input signals by the Ih current in a non-spiking neuron, the retinal rod bipolar cell.PloS one · 2007Article
- Cellular mechanisms underlying the pharmacological induction of phosphenes.British journal of pharmacology · 2007Review
- Synaptic transmission mediated by internal calcium stores in rod photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The intrinsic dynamics of bipolar cells and rod photoreceptors isolated from tiger salamanders were studied by a patch-clamp technique combined with estimation of effective impulse responses across a range of mean membrane voltages. An increase in external K(+) reduces the gain and speeds the response in bipolar cells near and below resting potential. High external K(+) enhances the inward rectification of membrane potential, an effect mediated by a fast, hyperpolarization-activated, inwardly rectifying potassium current (K(IR)). External Cs(+) suppresses the inward-rectifying effect of external K(+). The reversal potential of the current, estimated by a novel method from a family of impulse responses below resting potential, indicates a channel that is permeable predominantly to K(+). Its permeability to Na(+), estimated from Goldman-Hodgkin-Katz voltage equation, was negligible. Whereas the activation of the delayed-rectifier K(+) current causes bandpass behavior (i.e., undershoots in the impulse responses) in bipolar cells, activation of the K(IR) current does not. In contrast, a slow hyperpolarization-activated current (I(h)) in rod photoreceptors leads to pronounced, slow undershoots near resting potential. Differences in the kinetics and ion selectivity of hyperpolarization-activated currents in bipolar cells (K(IR)) and in rod photoreceptors (I(h)) confer different dynamical behavior onto the two types of neurons.
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