ArticleBiophysical journal2003
Analyzing heat capacity profiles of peptide-containing membranes: cluster formation of gramicidin A.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 77 citations in OpenAlex.
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- Carbon Dots-Biomembrane Interactions and Their Implications for Cellular Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Article
- Gramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles.Biophysical journal · 2019Article
- Apoptotic Bax at Oxidatively Stressed Mitochondrial Membranes: Lipid Dynamics and Permeabilization.Biophysical journal · 2017Article
- Biophysical investigation of the membrane-disrupting mechanism of the antimicrobial and amyloid-like peptide dermaseptin S9.PloS one · 2013Article
- Structural plasticity in self-assembling transmembrane β-sheets.Biophysical journal · 2011Article
- Tunable membrane binding of the intrinsically disordered dehydrin Lti30, a cold-induced plant stress protein.The Plant cell · 2011Article
- A lipocentric view of peptide-induced pores.European biophysics journal : EBJ · 2011Review
- The thermodynamics of simple biomembrane mimetic systems.Journal of pharmacy & bioallied sciences · 2011Article
- Molecular simulation of the effect of cholesterol on lipid-mediated protein-protein interactions.Biophysical journal · 2010Article
- Diffusion and partitioning of fluorescent lipid probes in phospholipid monolayers.Biophysical journal · 2009Article
- The temperature dependence of lipid membrane permeability, its quantized nature, and the influence of anesthetics.Biophysical journal · 2009Article
- The influence of vesicle size and composition on alpha-synuclein structure and stability.Biophysical journal · 2009Article
- A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicity.Biochemistry · 2008Article
- Molecular simulations of lipid-mediated protein-protein interactions.Biophysical journal · 2008Article
- On soliton propagation in biomembranes and nerves.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Direct visualization of asymmetric behavior in supported lipid bilayers at the gel-fluid phase transition.Biophysical journal · 2005Article
- Diffusion in two-component lipid membranes--a fluorescence correlation spectroscopy and monte carlo simulation study.Biophysical journal · 2005Article
- NMR Studies of lipid lateral diffusion in the DMPC/gramicidin D/water system: peptide aggregation and obstruction effects.Biophysical journal · 2004Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The analysis of peptide and protein partitioning in lipid membranes is of high relevance for the understanding of biomembrane function. We used statistical thermodynamics analysis to demonstrate the effect of peptide mixing behavior on heat capacity profiles of lipid membranes with the aim to predict peptide aggregation from c(P)-profiles. This analysis was applied to interpret calorimetric data on the interaction of the antibiotic peptide gramicidin A with lipid membranes. The shape of the heat capacity profiles was found to be consistent with peptide clustering in both gel and fluid phase. Applying atomic force microscopy, we found gramicidin A aggregates and established a close link between thermodynamics data and microscopic imaging. On the basis of these findings we described the effect of proteins on local fluctuations. It is shown that the elastic properties of the membrane are influenced in the peptide environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.