ArticleBiophysical journal2003
Prediction of 5-HT3 receptor agonist-binding residues using homology modeling.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 99 citations in OpenAlex.
- Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: In Vivo and in Silico Investigations on Receptor Binding Affinity.ChemistryOpen · 2025Article
- Article
- Differential Regulation of Human Serotonin Receptor Type 3A by Chanoclavine and Ergonovine.Molecules (Basel, Switzerland) · 2021Article
- Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3.Sub-cellular biochemistry · 2021Review
- Toward a multiscale modeling framework for understanding serotonergic function.Journal of psychopharmacology (Oxford, England) · 2017Review
- Article
- Bacterially expressed human serotonin receptor 3A is functionally reconstituted in proteoliposomes.Protein expression and purification · 2013Article
- 5-HT(3) receptors.The Journal of biological chemistry · 2012Review
- Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors.The Journal of physiology · 2011Article
- A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists.Molecular pharmacology · 2011Article
- Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor.Biophysical journal · 2010Article
- Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives.Journal of medicinal chemistry · 2010Article
- Structural basis of activation of cys-loop receptors: the extracellular-transmembrane interface as a coupling region.Molecular neurobiology · 2009Review
- Trans-cis switching mechanisms in proline analogues and their relevance for the gating of the 5-HT3 receptor.The journal of physical chemistry. B · 2009Article
- The 5-HT3 receptor--the relationship between structure and function.Neuropharmacology · 2009Review
- Loop B is a major structural component of the 5-HT3 receptor.Biophysical journal · 2008Article
- A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.Biochemistry · 2008Article
- Structural answers and persistent questions about how nicotinic receptors work.Frontiers in bioscience : a journal and virtual library · 2008Review
- 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function.European journal of pharmacology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
5-HT(3) receptors demonstrate significant structural and functional homology to other members of the Cys-loop ligand-gated ion channel superfamily. The extracellular domains of these receptors share similar sequence homology (approximately 20%) with Limnaea acetylcholine binding protein, for which an x-ray crystal structure is available. We used this structure as a template for computer-based homology modeling of the 5-HT(3) receptor extracellular domain. AutoDock software was used to dock 5-HT into the putative 5-HT(3) receptor ligand-binding site, resulting in seven alternative energetically favorable models. Residues located no more than 5 A from the docked 5-HT were identified for each model; of these, 12 were found to be common to all seven models with five others present in only certain models. Some docking models reflected the cation-pi interaction previously demonstrated for W183, and data from these and other studies were used to define our preferred models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.