ArticleBiophysical journal2003
Finite element simulations of acetylcholine diffusion in neuromuscular junctions.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Kinetics of Chemical Processes in the Human Brain. The Cholinergic Synapse-Mechanisms of Functioning and Control Methods.Doklady. Biochemistry and biophysics · 2020Article
- Kinetics of Chemical Processes in the Human Brain. Proton Blockade of Acetylcholinesterase and pH-Impulse in the Mechanism of Functioning of the Cholinergic Synapse.Doklady. Biochemistry and biophysics · 2020Article
- Improvements to the APBS biomolecular solvation software suite.Protein science : a publication of the Protein Society · 2018Article
- Hybrid finite element and Brownian dynamics method for charged particles.The Journal of chemical physics · 2016Article
- Synaptic bouton properties are tuned to best fit the prevailing firing pattern.Frontiers in computational neuroscience · 2014Article
- Hybrid finite element and Brownian dynamics method for diffusion-controlled reactions.The Journal of chemical physics · 2012Article
- A new 3D mass diffusion-reaction model in the neuromuscular junction.Journal of computational neuroscience · 2011Article
- A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction.BMC biophysics · 2011Article
- Poisson-Nernst-Planck Equations for Simulating Biomolecular Diffusion-Reaction Processes I: Finite Element Solutions.Journal of computational physics · 2010Article
- Finite element analysis of drug electrostatic diffusion: inhibition rate studies in N1 neuraminidase.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2009Article
- The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging.PLoS computational biology · 2008Article
- Finite element analysis of the time-dependent Smoluchowski equation for acetylcholinesterase reaction rate calculations.Biophysical journal · 2007Article
- Continuum simulations of acetylcholine diffusion with reaction-determined boundaries in neuromuscular junction models.Biophysical chemistry · 2007Article
- Continuum diffusion reaction rate calculations of wild-type and mutant mouse acetylcholinesterase: adaptive finite element analysis.Biophysical journal · 2004Article
- Finite element solution of the steady-state Smoluchowski equation for rate constant calculations.Biophysical journal · 2004Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A robust infrastructure for solving time-dependent diffusion using the finite element package FEtk has been developed to simulate synaptic transmission in a neuromuscular junction with realistic postsynaptic folds. Simplified rectilinear synapse models serve as benchmarks in initial numerical studies of how variations in geometry and kinetics relate to endplate currents associated with fast-twitch, slow-twitch, and dystrophic muscles. The flexibility and scalability of FEtk affords increasingly realistic and complex models that can be formed in concert with expanding experimental understanding from electron microscopy. Ultimately, such models may provide useful insight on the functional implications of controlled changes in processes, suggesting therapies for neuromuscular diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.