ReviewCurrent atherosclerosis reports2003
Cell physiology as a variable in gene transfer to endothelium.
Review in Current atherosclerosis reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Influence of cell physiological state on gene delivery to T lymphocytes by chimeric adenovirus Ad5F35.Scientific reports · 2016Article
- Cytokine-mediated downregulation of coxsackievirus-adenovirus receptor in endothelial cells.Journal of virology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The accessibility, distribution, and mass of endothelial cells make this cell type an ideal target for in vivo gene transfer. Genetic modification of endothelial cells has been contemplated for a variety of therapeutic purposes, including induction of angiogenesis, prevention of restenosis following angioplasty, suppression of vessel growth in tumors, and as a source of therapeutic proteins for treatment of hereditary or acquired disorders. In targeting endothelial cells for gene transfer, the complex physiology of these cells must be taken into account. Optimizing gene transfer to endothelial cells by working in concert with endothelial cell physiology may lead to a significant decrease in dose of vector required to achieve a therapeutic result, thus increasing the safety and utility of this approach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.