ArticleImmunology2003
X-chromosome-linked immune-deficient mice have B-1b cells.
Article in Immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Leishmania amazonensis impairs phagosome acidification in B-1 phagocytes as an unrecognized parasite infection and proliferation mechanism.Scientific reports · 2025Article
- From development to clinical success: the journey of established and next-generation BTK inhibitors.Investigational new drugs · 2025Review
- Sex differences in susceptibility to substance use disorder: Role for X chromosome inactivation and escape?Molecular and cellular neurosciences · 2023Review
- Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation.Frontiers in immunology · 2019Article
- Bruton's Tyrosine Kinase: An Emerging Key Player in Innate Immunity.Frontiers in immunology · 2017Review
- Transgenic mice expressing dominant-negative bright exhibit defects in B1 B cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- CD19 expression in B cells is important for suppression of contact hypersensitivity.The American journal of pathology · 2007Article
- Induction of in vivo antipolysaccharide immunoglobulin responses to intact Streptococcus pneumoniae is more heavily dependent on Btk-mediated B-cell receptor signaling than antiprotein responses.Infection and immunity · 2006Article
- B-1 cells are pivotal for in vivo inflammatory giant cell formation.International journal of experimental pathology · 2005Article
- Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis.Immunology · 2005Article
- Interleukin-10 secreted by B-1 cells modulates the phagocytic activity of murine macrophages in vitro.Immunology · 2004Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The B lymphocyte subsets of X-chromosome-linked immune-deficient (XID) mice were examined by flow cytometric analyses of spleen and peritoneal cells. As shown in prior studies, young adult XID mice had reduced representation of the CD5+ (B-1a) subset in their peritoneal cavity. However, the CD11b+ (B-1b) B-cell subset was present and exhibited the IgM(hi) CD45(lo) CD23- phenotype characteristic of most B-1 cells. Although present at a lower frequency than that found in their normal counterparts, B-1b cells were evident in CBA/N and (XD2J)F1 male mice. With increasing age, B-1b cell number increased and in the oldest XID mice were present as B-cell chronic lymphocytic leukaemia. These results show that XID mice do have B-1 cells, particularly the B-1b subset.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.