ArticleJournal of periodontology2003
Gene therapy of bone morphogenetic protein for periodontal tissue engineering.
Article in Journal of periodontology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 183 citations in OpenAlex.
- The extracellular vesicle-based treatment: a developing strategy for periodontal diseases.Frontiers in immunology · 2025Review
- Dental stem cell dynamics in periodontal ligament regeneration: from mechanism to application.Stem cell research & therapy · 2024Review
- Supra-Alveolar Bone Regeneration: Progress, Challenges, and Future Perspectives.Composites. Part B, Engineering · 2024Article
- Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration.The Japanese dental science review · 2022Review
- BMP Gene-Immobilization to Dental Implants Enhances Bone Regeneration.Advanced materials interfaces · 2022Article
- Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects.Frontiers in bioengineering and biotechnology · 2021Review
- Biomimetic Aspects of Oral and Dentofacial Regeneration.Biomimetics (Basel, Switzerland) · 2020Review
- Sclerostin antibody stimulates periodontal regeneration in large alveolar bone defects.Scientific reports · 2020Article
- rhBMP-2 Pre-Treated Human Periodontal Ligament Stem Cell Sheets Regenerate a Mineralized Layer Mimicking Dental Cementum.International journal of molecular sciences · 2020Article
- Biosafety, and improvement of osteoporosis in cage layers through using chOPG protein.Saudi journal of biological sciences · 2020Article
- Gene Delivery Therapeutics in the Treatment of Periodontitis and Peri-Implantitis: A State of the Art Review.International journal of molecular sciences · 2019Review
- Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration.Journal of functional biomaterials · 2019Review
- Micropatterned Scaffolds with Immobilized Growth Factor Genes Regenerate Bone and Periodontal Ligament-Like Tissues.Advanced healthcare materials · 2018Article
- Effect of sustained PDGF nonviral gene delivery on repair of tooth-supporting bone defects.Gene therapy · 2017Article
- Mandibular Jaw Bone Regeneration Using Human Dental Cell-Seeded Tyrosine-Derived Polycarbonate Scaffolds.Tissue engineering. Part A · 2016Article
- Regenerative Medicine for Periodontal and Peri-implant Diseases.Journal of dental research · 2016Review
- Integration of 3D Printed and Micropatterned Polycaprolactone Scaffolds for Guidance of Oriented Collagenous Tissue Formation In Vivo.Advanced healthcare materials · 2016Article
- Tissue engineering for bone regeneration and osseointegration in the oral cavity.Dental materials : official publication of the Academy of Dental Materials · 2015Review
- Image-based, fiber guiding scaffolds: a platform for regenerating tissue interfaces.Tissue engineering. Part C, Methods · 2014Article
- Dual delivery of rhPDGF-BB and bone marrow mesenchymal stromal cells expressing the BMP2 gene enhance bone formation in a critical-sized defect model.Tissue engineering. Part A · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe reconstruction of lost periodontal support including bone, ligament, and cementum is a major goal of therapy. Bone morphogenetic proteins (BMPs) have shown much potential in the regeneration of the periodontium. Limitations of BMP administration to periodontal lesions include need for high-dose bolus delivery, BMP transient biological activity, and low bioavailability of factors at the wound site. Gene transfer offers promise as an alternative treatment strategy to deliver BMPs to periodontal tissues.
methodsThis study utilized ex vivo BMP-7 gene transfer to stimulate tissue engineering of alveolar bone wounds. Syngeneic dermal fibroblasts (SDFs) were transduced ex vivo with adenoviruses encoding either green fluorescent protein (Ad-GFP or control virus), BMP-7 (Ad-BMP-7), or an antagonist of BMP bioactivity, noggin (Ad-noggin). Transduced cells were seeded onto gelatin carriers and then transplanted to large mandibular alveolar bone defects in a rat wound repair model.
resultsAd-noggin treatment tended to inhibit osteogenesis as compared to the control-treated and Ad-BMP-7-treated specimens. The osseous lesions treated by Ad-BMP-7 gene delivery demonstrated rapid chrondrogenesis, with subsequent osteogenesis, cementogenesis and predictable bridging of the periodontal bone defects.
conclusionThese results demonstrate the first successful evidence of periodontal tissue engineering using ex vivo gene transfer of BMPs and offers a new approach for repairing periodontal defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.