ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2003
Hindlimb glucose and lactate metabolism during umbilical cord compression and acute hypoxemia in the late-gestation ovine fetus.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- Effects of administration of sildenafil citrate and amino acids on selected physiological, blood gas and biochemical parameters in pregnant twin-bearing sheep in late gestation.Veterinary and animal science · 2026Article
- Maternal cardiometabolic dysfunction and fetal sex-specific alterations to uterine vascular reactivity in an ovine model of obesity during pregnancy.The Journal of physiology · 2026Article
- Chronic Hypoxia in an EXTrauterine Environment for Neonatal Development Impairs Lung Development.American journal of respiratory cell and molecular biology · 2025Article
- Metabolic Consequences of Glucocorticoid Exposure before Birth.Nutrients · 2022Review
- Breath of Life: Heart Disease Link to Developmental Hypoxia.Circulation · 2021Article
- Altered Cardiovascular Defense to Hypotensive Stress in the Chronically Hypoxic Fetus.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Hypertension Programmed in Adult Hens by Isolated Effects of Developmental Hypoxia In Ovo.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Fetal cardiovascular response to acute hypoxia during maternal anesthesia.Physiological reports · 2020Article
- Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep.The Journal of physiology · 2018Article
- Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro.The Journal of endocrinology · 2017Article
- The fetal brain sparing response to hypoxia: physiological mechanisms.The Journal of physiology · 2016Review
- Calcitonin gene-related peptide antagonism attenuates the haemodynamic and glycaemic responses to acute hypoxaemia in the late gestation sheep fetus.The Journal of physiology · 2005Article
- Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals?The Journal of physiology · 2004Review
- Adrenocortical responsiveness is blunted in twin relative to singleton ovine fetuses.The Journal of physiology · 2004Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The metabolic adaptation of the hindlimb in the fetus to a reversible period of adverse intrauterine conditions and, subsequently, to a further episode of acute hypoxemia has been examined. Sixteen sheep fetuses were chronically instrumented with vascular catheters and transit-time flow probes. In nine of these fetuses, umbilical blood flow was reversibly reduced by 30% from baseline for 3 days (umbilical cord compression), while the remaining fetuses acted as sham-operated, age-matched controls. Acute hypoxemia was subsequently induced in all fetuses by reducing maternal fractional inspired oxygen concentration for 1 h. Paired hindlimb arteriovenous blood samples were taken at appropriate intervals during cord compression and acute hypoxemia, and by using femoral blood flow and the Fick principle, substrate delivery, uptake, and output were calculated. Umbilical cord compression reduced blood oxygen content and delivery to the hindlimb and increased hindlimb oxygen extraction and blood glucose and lactate concentration in the fetus. However, hindlimb glucose and oxygen consumption were unaltered during umbilical cord compression. In contrast, hindlimb oxygen delivery and uptake were significantly reduced in all fetuses during subsequent acute hypoxemia, but glucose extraction, oxygen extraction, and hindlimb lactate output significantly increased in sham-operated control fetuses only. Preexposure of the fetus to a temporary period of adverse intrauterine conditions alters the metabolic response of the fetal hindlimb to subsequent acute stress. Additional data suggest that circulating blood lactate may be derived from sources other than the fetal hindlimb under these circumstances. The lack of hindlimb lactate output during acute hypoxemia in umbilical cord-compressed fetuses, despite a significant fall in oxygen delivery to and uptake by the hindlimb, suggests that the fetal hindlimb may not respire anaerobically after exposure to adverse intrauterine conditions. hypoxia
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