Trial reportEuropean journal of applied physiology2003
Functional and biochemical properties of chronically stimulated human skeletal muscle.
Trial report in European journal of applied physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03793647 (Electrical Muscle Stimulation in Severely Deconditioned Congestive Heart Failure Patients- a Prospective, Randomized, Controlled Trial), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electrical Muscle Stimulation in Severely Deconditioned Congestive Heart Failure Patients- a Prospective, Randomized, Controlled Trial
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Effectiveness of neuromuscular electrostimulation in COPD subjects on mechanical ventilation. A systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2022Pooled it
- Metabolic and structural changes in lower-limb skeletal muscle following neuromuscular electrical stimulation: a systematic review.PloS one · 2013Pooled it
- Handcycling with concurrent lower body low-frequency electromyostimulation significantly increases acute oxygen uptake in elite wheelchair basketball players: an acute crossover trial.Journal of rehabilitation medicine · 2024Trial
- Trial
- Metabolic load during strength training or NMES in individuals with COPD: results from the DICES trial.BMC pulmonary medicine · 2014Trial
- Neuromuscular Activity Determines, at Least in Part, the Motoneuron, Nerve and Muscle Properties Under Normal Conditions and After Nerve Injury.International journal of molecular sciences · 2025Review
- Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training.Sports medicine and health science · 2025Review
- Frequency-dependent effects of superimposed NMES on spinal excitability in upper and lower limb muscles.Heliyon · 2024Article
- The Effect of Whole-Body Electromyostimulation Program on Physical Performance and Selected Cardiometabolic Markers in Obese Young Females.Medicina (Kaunas, Lithuania) · 2024Article
- NMES superimposed on movement is equally effective as heavy slow resistance training in patellar tendinopathy.Journal of musculoskeletal & neuronal interactions · 2022Article
- Home-Based Nonoperative-Side Quadriceps Neuromuscular Electrical Stimulation Prevents Muscle Weakness Following Anterior Cruciate Ligament Reconstruction.Journal of clinical medicine · 2022Article
- Effects of electrode size and placement on comfort and efficiency during low-intensity neuromuscular electrical stimulation of quadriceps, hamstrings and gluteal muscles.BMC sports science, medicine & rehabilitation · 2022Article
- Neuromuscular Electrical Stimulation in Patients With Severe COVID-19 Associated With Sepsis and Septic Shock.Frontiers in medicine · 2022Article
- Article
- Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle.Mechanisms of ageing and development · 2021Review
- Changes in Physical Fitness After 12 Weeks of Structured Concurrent Exercise Training, High Intensity Interval Training, or Whole-Body Electromyostimulation Training in Sedentary Middle-Aged Adults: A Randomized Controlled Trial.Frontiers in physiology · 2019Article
- Whole-Body Electromyostimulation Improves Performance-Related Parameters in Runners.Frontiers in physiology · 2018Article
- Functional Exercise Training and Undulating Periodization Enhances the Effect of Whole-Body Electromyostimulation Training on Running Performance.Frontiers in physiology · 2018Article
- Reply to: Could superimposed electromyostimulation be an effective training to improve aerobic and anaerobic capacity? Methodological considerations for its development.European journal of applied physiology · 2017Article
- Aspects of physical medicine and rehabilitation in the treatment of deconditioned patients in the acute care setting: the role of skeletal muscle.Wiener medizinische Wochenschrift (1946) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was undertaken to investigate in a randomized controlled trial the effects of chronic (10 weeks, 4 h per day, 7 days per week) low-frequency (15 Hz) stimulation (CLFS) of the knee extensor and hamstring muscles of both legs in healthy volunteers via surface electrodes. A control group (n=10) underwent the same treatment (sham stimulation) as the CLFS-treated group (n=10), except that stimulation intensity was kept at a level which did not evoke contractions. Biopsy samples were taken before the onset and after cessation of stimulation from the right vastus lateralis muscle of all subjects. The biopsy samples were analyzed for changes in myosin heavy chain (MHC) isoforms and activities of citrate synthase (CS) and glyceraldehyde phosphate dehydrogenase (GAPDH) as markers of aerobic-oxidative and anaerobic pathways of energy metabolism, respectively. In addition, functional properties, i.e., oxygen consumption (VO(2)) and work capacity, were assessed. Sham stimulation did not affect the functional properties and had no detectable effect on MHC isoform and enzyme activity patterns. Conversely, CLFS induced changes in the MHC isoform pattern in the fast-to-slow direction with an approximately 20% decrease in the relative concentration of MHCIId/x (from 28% to 22%) and an approximately 10% increase in the relative concentration of MHCI (from 30% to 34%). In addition, CLFS led to a approximately 9% increase in the activity of CS concomitant with an approximatley 7% decrease in the activity of GAPDH. This increase in aerobic-oxidative capacity was accompanied by improved work capacity and VO(2) at the anaerobic threshold by 26% and 20%, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.