ReviewEndocrine pathology2002
Molecular pathobiology of thyroid neoplasms.
Review in Endocrine pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 79 citations in OpenAlex.
- Estrogens and stem cells in thyroid cancer.Frontiers in endocrinology · 2014Review
- ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence.Oncogene · 2012Article
- Recent advances in molecular diagnosis of thyroid cancer.Journal of thyroid research · 2011Article
- Modeling thyroid cancer in the mouse.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2009Review
- Identification of differentially expressed genes in papillary thyroid cancers.Yonsei medical journal · 2009Article
- NrCAM, a neuronal system cell-adhesion molecule, is induced in papillary thyroid carcinomas.British journal of cancer · 2007Article
- Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
- New prognostic scales LAST-1 and LAST-2: supporting prediction and staging of thyroid cancer.World journal of surgery · 2006Article
- ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy.Annals of surgery · 2005Article
- BRAF copy number gains in thyroid tumors detected by fluorescence in situ hybridization.Endocrine pathology · 2005Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumors of thyroid follicular cells provide a very interesting model to understand the development of human cancer. It is becoming apparent that distinct molecular events are associated with specific stages in a multistep tumorigenic process with good genotype/ phenotype correlation. For instance, mutations of the gsp and thyroid-stimulating hormone receptor genes are associated with benign hyperfunctioning thyroid nodules and adenomas while alterations of other specific genes, such as oncogenic tyrosine kinase alterations (RET/PTC, TRK) in papillary carcinoma and the newly discovered PAX8/peroxisome proliferator-activated receptor gamma rearrangement, are distinctive features of cancer. Although activating RAS mutations occur at all stages of thyroid tumorigenesis, evidence is accumulating that they may also play an important role in tumor progression, a role that is well documented for p53. Environmental factors (iodine deficiency, ionizing radiations) have been shown to play a crucial role in promoting the development of thyroid cancer, influencing both its genotypic and phenotypic features. It is possible that the follicular thyroid cell has unique ways to respond to DNA damage. Similarly to leukemia or sarcomas (and unlike most epithelial cancers), numerous specific rearrangements are being discovered in thyroid cancer suggesting preferential activation of DNA repair instead of cell death programs after environmentally induced genetic alterations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.