ArticleThe Journal of physiology2003
Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 72 citations in OpenAlex.
- What Dale never said: multiple incarnations of Dale's law from the birth of pharmacology to modeling brain circuits.Journal of neurophysiology · 2026Review
- Presynaptic gating of monkey proprioceptive signals for proper motor action.Nature communications · 2023Article
- Gate control of sensory neurotransmission in peripheral ganglia by proprioceptive sensory neurons.Brain : a journal of neurology · 2023Article
- Nicotinic receptor modulation of primary afferent excitability with selective regulation of Aδ-mediated spinal actions.Journal of neurophysiology · 2021Article
- Disrupted Association of Sensory Neurons With Enveloping Satellite Glial Cells in Fragile X Mouse Model.Frontiers in molecular neuroscience · 2021Article
- Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors.Brain sciences · 2020Article
- Chloride - The Underrated Ion in Nociceptors.Frontiers in neuroscience · 2020Review
- Contribution of GABAergic modulation in DRGs to electroacupuncture analgesia in incisional neck pain rats.Journal of pain research · 2019Article
- Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception.Biomolecules & therapeutics · 2018Review
- Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.Anesthesia and analgesia · 2017Review
- Acute inflammation reveals GABAPhysiological reports · 2017Article
- Current and Future Issues in the Development of Spinal Agents for the Management of Pain.Current neuropharmacology · 2017Review
- Transient, activity dependent inhibition of transmitter release from low threshold afferents mediated by GABAA receptors in spinal cord lamina III/IV.Molecular pain · 2015Article
- Silencing the α2 subunit of γ-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury.Anesthesiology · 2015Article
- Peripheral cardiac sympathetic hyperactivity in cardiovascular disease: role of neuropeptides.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- Expression of gamma-aminobutyric acid type A receptor α2 subunit in the dorsal root ganglion of rats with sciatic nerve injury.Neural regeneration research · 2012Article
- Molecular and functional expression of cation-chloride cotransporters in dorsal root ganglion neurons during postnatal maturation.Journal of neurophysiology · 2012Article
- The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons.Nature neuroscience · 2012Article
- Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Regulation of GABA(A) receptor dynamics by interaction with purinergic P2X(2) receptors.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The role of endogenous GABA and ATP in regulating transmitter release from primary afferent terminals in the superficial dorsal horn of the spinal cord is still controversial. ATP is co-released with GABA from some inhibitory dorsal horn neurons raising the possibility that ATP could act in concert with GABA to regulate transmitter release from primary afferent terminals if receptors to both transmitters are expressed there. Using electrophysiology together with immunocytochemistry, we have investigated the expression of ATP-gated P2X and GABAA receptors by identified subpopulations of dorsal root ganglion (DRG) neurons known to project primarily to the superficial dorsal horn. Expression of the heat-sensitive vanilloid receptor 1 (VR1) and sensitivity to capsaicin were used to characterize DRG neurons sensitive to noxious heat. Both P2X and GABAA receptors were expressed on the majority of DRG neurons examined. Recording compound action potentials (CAPs) from dorsal roots in the presence of muscimol, alpha,beta-methylene-ATP (alpha,beta-meATP) or capsaicin resulted in depression of CAP in the slow and medium conducting fibres, indicating cognate receptor expression on the small diameter axons. Dorsal root-evoked dorsal root potentials (DR-DRPs), reflecting depolarization of primary afferent terminals by endogenously released substances, were depressed by the GABAA receptor antagonist SR95531 and alpha,beta-meATP. These results suggest that GABAA and P2X receptors are expressed on DRG cell bodies and slow fibre axons, many of which are heat-nociceptive. These fibres project to the superficial lamina of the dorsal horn where the receptors may function to modulate transmitter release near their central terminals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.