ArticleMolecular and cellular biology2003
NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 86 citations in OpenAlex.
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- Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells.Archives of toxicology · 2017Article
- Metabolic stress in the myocardium: adaptations of gene expression.Journal of molecular and cellular cardiology · 2013Review
- Involvement of transcription initiation factor IIB in the light-induced death of rat retinal ganglion cells in vivo.Journal of molecular histology · 2013Article
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- Novel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation.The Journal of biological chemistry · 2012Article
- Tax protein-induced expression of antiapoptotic Bfl-1 protein contributes to survival of human T-cell leukemia virus type 1 (HTLV-1)-infected T-cells.The Journal of biological chemistry · 2012Article
- Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process.International journal of cell biology · 2012Article
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- Pathophysiology of ischemic acute kidney injury.Nature reviews. Nephrology · 2011Review
- NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells.BMC cancer · 2010Article
- Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma.Blood · 2010Article
- Pitx2-dependent occupancy by histone deacetylases is associated with T-box gene regulation in mammalian abdominal tissue.The Journal of biological chemistry · 2010Article
- Meningococcal porin PorB prevents cellular apoptosis in a toll-like receptor 2- and NF-kappaB-independent manner.Infection and immunity · 2010Article
- Short communication: activation of latent HIV type 1 gene expression by suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor approved for use to treat cutaneous T cell lymphoma.AIDS research and human retroviruses · 2009Article
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- Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- TNF-induced oscillations in combinatorial transcription factor binding.Biochemical and biophysical research communications · 2008Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Expression of the prosurvival Bcl-2 homologue Bfl-1/A1 is induced by NF-kappa B-activating stimuli, while B and T cells from c-rel knockout mice show an absolute defect in bfl-1/a1 gene activation. Here, we demonstrate NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of bfl-1. Binding of NF-kappa B subunit c-Rel to DNA nucleated the concerted binding of transcription factors AP-1 and C/EBP beta to the 5'-regulatory region of bfl-1. Optimal stability of the complex was dependent on proper orientation and phasing of the NF-kappa B site. Chromatin immunoprecipitation analyses demonstrated that T-cell activation triggers in vivo binding of endogenous c-Rel, c-Jun, C/EBP beta, and HMG-IC to the bfl-1 regulatory region, coincident with selective recruitment of coactivators TAFII250 and p300, SWI/SNF chromatin remodeling factor component BRG-1, and basal transcription factors TATA-binding protein (TBP) and TFIIB, as well as hyperacetylation of histones H3 and H4. These results highlight a critical role for NF-kappa B in bfl-1 transcription and point to the need for a complex and precise regulatory network to control bfl-1 expression. To our knowledge, this is the first demonstration of enhanceosome-mediated regulation of a cell death inhibitor.
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