ArticleHuman genetics2003
Evidence for asthma susceptibility genes on chromosome 11 in an African-American population.
Article in Human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005500 (Collaborative Studies on the Genetics of Asthma), which is not on this map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Collaborative Studies on the Genetics of Asthma (CSGA)
Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Association between CC10 +38A/G polymorphism and asthma risk: A meta-analysis.Pakistan journal of medical sciences · 2013Review
- The challenge of asthma in minority populations.Clinical reviews in allergy & immunology · 2012Review
- Genetic variations in chemoattractant receptor expressed on Th2 cells (CRTH2) is associated with asthma susceptibility in Chinese children.Molecular biology reports · 2009Article
- Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region.Human genetics · 2008Article
- African Americans with asthma: genetic insights.Proceedings of the American Thoracic Society · 2007Review
- A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q.BMC genetics · 2006Article
- Asthma in Hispanics.American journal of respiratory and critical care medicine · 2006Review
- Association between asthma-related phenotypes and the CC16 A38G polymorphism in an unselected population of young adult Danes.Immunogenetics · 2005Article
- Association of an intragenic microsatellite marker in the CC16 gene with asthma in the Indian population.Journal of human genetics · 2004Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
Initial genome-wide scan data provided suggestive evidence for linkage of the asthma phenotype in African-American (AA), but not Caucasian, families to chromosome 11q markers (peak at D11S1985; LOD=2). To refine this region, mapping analysis of 91 AA families (51 multiplex families and 40 asthmatic case-parent trios) was performed with an additional 17 markers flanking the initial peak linkage marker. Multipoint analyses of the 51 multiplex families yielded significant evidence of linkage with a peak non-parametric linkage score of 4.38 at marker D11S1337 (map position 68.6 cM). Furthermore, family-based association and transmission disequilibrium tests conducted on all 91 families showed significant evidence of linkage in the presence of disequilibrium for several individual markers in this region. A putative susceptibility locus was estimated to be at map position 70.8 cM with a confidence interval spanning the linkage peak. Evidence from both linkage and association analyses suggest that this region of chromosome 11 contains one or more susceptibility genes for asthma in these AA families.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.