Does immunonutrition in patients with sepsis do more harm than good?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Immunonutrition in critically ill patients: a systematic review and analysis of the literature.Intensive care medicine · 2008
   Pooled it
2. Early enteral immunonutrition vs. parenteral nutrition in critically ill patients without severe sepsis: a randomized clinical trial.Intensive care medicine · 2006
   Trial
3. Comparative effects of early randomized immune or non-immune-enhancing enteral nutrition on cytokine production in children with septic shock.Intensive care medicine · 2005
   Trial
4. Clinical outcome of immunonutrition in a heterogeneous intensive care population.Intensive care medicine · 2005
   Trial
5. Immunonutrition for traumatic brain injury in children and adolescents: protocol for a systematic review and meta-analysis.BMJ open · 2020
   Article
6. Nutrition and metabolism in burn patients.Burns & trauma · 2017
   Review
7. The evolution of nutrition in critical care: how much, how soon?Critical care (London, England) · 2013
   Review
8. Arginine de novo and nitric oxide production in disease states.American journal of physiology. Endocrinology and metabolism · 2012
   Review
9. Glutamine randomized studies in early life: the unsolved riddle of experimental and clinical studies.Clinical & developmental immunology · 2012
   Review
10. Is glutamine still an important precursor of citrulline?American journal of physiology. Endocrinology and metabolism · 2011
    Article
11. Clinical review: Optimizing enteral nutrition for critically ill patients--a simple data-driven formula.Critical care (London, England) · 2011
    Review
12. Molecular mechanisms of pharmaconutrients.The Journal of surgical research · 2010
    Review
13. Update on postinjury nutrition.Current opinion in critical care · 2008
    Review
14. Enteral glutamine: a novel mediator of PPARgamma in the postischemic gut.Journal of leukocyte biology · 2008
    Review
15. Effects of polyenylphosphatidylcholine on cytokines, nitrite/nitrate levels, antioxidant activity and lipid peroxidation in rats with sepsis.Intensive care medicine · 2004
    Article
16. High plasma arginine concentrations in critically ill patients suffering from hepatic failure.European journal of clinical nutrition · 2004
    Article
17. Differential effects of luminal arginine and glutamine on metalloproteinase production in the postischemic gut.JPEN. Journal of parenteral and enteral nutrition
    Article

Corrections and comments

• Comment on
  Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial.2003

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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