ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2003
Ryanodine and dihydropyridine receptor binding in ventricular cardiac muscle of fish with different temperature preferences.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 33 citations in OpenAlex.
- The RyR-like-FKBP12-PKA Complex Regulates Intracellular CaInternational journal of molecular sciences · 2026Article
- Effects of seasonal acclimatization on thermal tolerance of inward currents in roach (Rutilus rutilus) cardiac myocytes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Calcium response of KCl-excited populations of ventricular myocytes from the European sea bass (Dicentrarchus labrax): a promising approach to integrate cell-to-cell heterogeneity in studying the cellular basis of fish cardiac performance.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Article
- Species- and chamber-specific responses of 12 kDa FK506-binding protein to temperature in fish heart.Fish physiology and biochemistry · 2014Article
- Temperature dependence of sarco(endo)plasmic reticulum Ca2+ ATPase expression in fish hearts.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2013Article
- Sarcoplasmic reticulum: a key factor in cardiac contractility of sea bass Dicentrarchus labrax and common sole Solea solea during thermal acclimations.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2013Article
- Triclosan impairs swimming behavior and alters expression of excitation-contraction coupling proteins in fathead minnow (Pimephales promelas).Environmental science & technology · 2013Article
- Temperature effects on Ca2+ cycling in scombrid cardiomyocytes: a phylogenetic comparison.The Journal of experimental biology · 2011Article
- Warm fish with cold hearts: thermal plasticity of excitation-contraction coupling in bluefin tuna.Proceedings. Biological sciences · 2011Article
- Temperature acclimation has no effect on ryanodine receptor expression or subcellular localization in rainbow trout heart.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2009Article
- Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart.American journal of physiology. Cell physiology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ca(2+)-induced Ca2+ release (CICR) mechanism of cardiac excitation-contraction (e-c) coupling is dependent on the close apposition between the sarcolemmal dihydropyridine receptors (DHPR) and the sarcoplasmic reticulum (SR) ryanodine receptors (RyR). In particular, high RyR/DHPR ratio is considered to reflect strong dependence on SR Ca2+ stores for the intracellular Ca2+ transient. To indirectly evaluate the significance of CICR in fish hearts, densities of cardiac DHPRs and RyRs were compared in ventricular homogenates of three fish species (burbot, rainbow trout, and crucian carp) and adult rat by [3H] PN200-110 and [3H] ryanodine binding. The density of RyRs was significantly (P<0.05) higher in the adult rat (124+/-10 channels/microm3 myocyte volume) than in any of the fish species. Among the fish species, cold-acclimated (4 degrees C) trout had more RyRs than burbot, and crucian carp. The density of DHPRs was highest in the trout heart. RyR/DHPR ratio was significantly (P<0.05) higher in rat (4.1+/-0.5) than in the fish hearts (varying from 0.97+/-0.16 to 1.91+/-0.49) suggesting that "mammalian type" CICR is less important during e-c coupling in fish ventricular myocytes. In rainbow trout, acclimation to cold did not affect the RyR/DHPR ratio, while in crucian carp it was depressed in cold-acclimated animals (4 degrees C; 0.97+/-0.16) when compared to warm-acclimated fish (23 degrees C; 1.91+/-0.49). Although RyR/DHPR ratios were relatively low in fish hearts, there was a close correlation (r2=0.78) between the RyR/DHPR ratio and the magnitude of the Ry-sensitive component of contraction in ventricular muscle among the fish species examined in this study.
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