Trial reportInternational journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity2003
No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects.
Trial report in International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00716170 (The Role of GIP, GLP-1 and GLP-2 in Type 2 Diabetic Hyperglucagonemia), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of GIP, GLP-1 and GLP-2 in Type 2 Diabetic Hyperglucagonemia
Who cites it
23 citing papers in PubMed, 100 citations in OpenAlex.
- Glucagon-Like Peptide 2 Inhibits Postprandial Gallbladder Emptying in Man: A Randomized, Double-Blinded, Crossover Study.Clinical and translational gastroenterology · 2020Trial
- Glucagon-Like Peptides 1 and 2 Are Involved in Satiety Modulation After Modified Biliopancreatic Diversion: Results of a Pilot Study.Obesity surgery · 2018Trial
- GLP-1 and GLP-2 Levels are Correlated with Satiety Regulation After Roux-en-Y Gastric Bypass: Results of an Exploratory Prospective Study.Obesity surgery · 2017Trial
- A randomized, double-blind, placebo-controlled, multiple-dose, parallel-group clinical trial to assess the effects of teduglutide on gastric emptying of liquids in healthy subjects.BMC gastroenterology · 2014Trial
- Glucose-Dependent Effects of Exogenous Glucagon-Like Peptide-2 on Circulating Glucagon Levels in Healthy Men.Journal of the Endocrine Society · 2026Article
- Incretin hormones and obesity.The Journal of physiology · 2025Review
- The Possible Involvement of Glucagon-like Peptide-2 in the Regulation of Food Intake through the Gut-Brain Axis.Nutrients · 2024Review
- RISING STARS: Endocrine regulation of metabolic homeostasis via the intestine and gut microbiome.The Journal of endocrinology · 2023Review
- The Enteroendocrine System in Obesity.Handbook of experimental pharmacology · 2022Article
- MECHANISMS IN ENDOCRINOLOGY: The gut-brain axis: regulating energy balance independent of food intake.European journal of endocrinology · 2021Review
- Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications.International journal of molecular sciences · 2018Review
- Gut Hormones and Regulation of Food Intake in Birds.The journal of poultry science · 2017Review
- Bile Acid Signaling Pathways from the Enterohepatic Circulation to the Central Nervous System.Frontiers in neuroscience · 2017Review
- Glucagon-related peptides and the regulation of food intake in chickens.Animal science journal = Nihon chikusan Gakkaiho · 2016Review
- The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets.Journal of animal science and biotechnology · 2016Article
- Association between protein signals and type 2 diabetes incidence.Acta diabetologica · 2013Article
- Glucagon-like peptide-2 (GLP-2) increases net amino acid utilization by the portal-drained viscera of ruminating calves.Animal : an international journal of animal bioscience · 2012Article
- Intestinal hormones and growth factors: effects on the small intestine.World journal of gastroenterology · 2009Review
- The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas.Diabetologia · 2007Article
- Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects.Diabetologia · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the effect of a GLP-2 infusion on appetite sensations and ad libitum energy intake in healthy, normal weight humans.
designThe experiment was performed in a randomised, blinded, and placebo-controlled crossover design. Placebo or GLP-2 was infused (infusion rate of 25 pmol/kg body wth) for 4.5 h. SUBJECTS: A total of 18 healthy, normal weight young subjects participated; eight women and 10 men. MEASUREMENTS: During the infusion, subjects recorded their appetite sensations every 30 min using visual analogue scales, and blood was sampled frequently. After 2 h of infusion, an ad libitum meal, consisting of sandwiches, was served.
resultsThe concentration of GLP-2 was significantly higher during the GLP-2 infusion compared with placebo (P<0.0001) and increased further in both conditions in response to the meal. Neither appetite sensations, nor palatability of the test meals, or energy intake were different on the two occasions. Glucose, GLP-1, insulin, and GIP responses were also unaffected by the infusion, whereas glucagon levels were higher during the GLP-2 treatment (P<0.05).
conclusionCirculating GLP-2 in physiological concentrations does not seem to play a significant role in human appetite regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.