ArticleProstate cancer and prostatic diseases2003
Characterization of expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in prostate cancer cell lines.
Article in Prostate cancer and prostatic diseases, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- The Role of the Metzincin Superfamily in Prostate Cancer Progression: A Systematic-Like Review.International journal of molecular sciences · 2021Pooled it
- Intratumoral immune heterogeneity of prostate cancer characterized by typing and hub genes.Journal of cellular and molecular medicine · 2023Article
- Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis.Cancers · 2022Review
- HLA-BAT1 alters migration, invasion and pro-inflammatory cytokines in prostate cancer.Frontiers in oncology · 2022Article
- Interleukin-7 Contributes to the Invasiveness of Prostate Cancer Cells by Promoting Epithelial-Mesenchymal Transition.Scientific reports · 2019Article
- Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling.American journal of physiology. Cell physiology · 2018Article
- Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis.Oncology letters · 2017Article
- Blood Droplet-Based Cancer Diagnosis via Proteolytic Activity Measurement in Cancer Progression.Theranostics · 2017Article
- Androgen deprivation in LNCaP prostate tumour xenografts induces vascular changes and hypoxic stress, resulting in promotion of epithelial-to-mesenchymal transition.British journal of cancer · 2016Article
- miR-132 can inhibit glioma cells invasion and migration by target MMP16 in vitro.OncoTargets and therapy · 2015Article
- High-content adhesion assay to address limited cell samples.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Finasteride inhibits human prostate cancer cell invasion through MMP2 and MMP9 downregulation.PloS one · 2013Article
- The role of EZH2 in the regulation of the activity of matrix metalloproteinases in prostate cancer cells.PloS one · 2012Article
- LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells.Molecular cancer · 2011Article
- Matrix metalloproteinases and angiogenic factors: predictors of survival after radical prostatectomy for clinically organ-confined prostate cancer?The American journal of pathology · 2010Article
- Study of matrix metalloproteinases and their inhibitors in prostate cancer.British journal of cancer · 2010Article
- Bone marrow stromal cells enhance prostate cancer cell invasion through type I collagen in an MMP-12 dependent manner.International journal of cancer · 2008Article
- Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer.BMC cancer · 2008Article
- In vitro irradiation of basement membrane enhances the invasiveness of breast cancer cells.British journal of cancer · 2007Article
- The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression.The EMBO journal · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stromal expression of some matrix metalloproteinases (MMPs) has been associated with increasing tumour burden in prostate cancer. We investigated the expression of mRNA (by RT-PCR) and protein (by zymography and western blotting) of MMPs and endogenous inhibitors (tissue inhibitors of metalloproteinases, TIMPs) in two parent epithelial prostate cancer cell lines and sublines of increasing invasive/metastatic potential. Expression of membrane type MMPs, MT1-MMP and MT3-MMP mRNA was higher in PC3-derived than in LNCaP-derived lines, whereas MT2-MMP mRNA expression was higher in the LNCaPderived than in PC3-derived cell lines. Active MT1, MT2 and MT3-MMP protein levels were similar in all lines, but processed MT-MMPs, indicative of latent MMP activation, were increased in more aggressive sublines. Expression of MMP-1, MMP-13 and TIMP-1 was higher in the more aggressive sublines and may be implicated in invasive/metastatic ability. Regulation of MMP-1 and MMP-13 expression may offer important therapeutic options for treating patients with prostate cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.