ArticleJournal of virology2003
Murine coronavirus-induced hepatitis: JHM genetic background eliminates A59 spike-determined hepatotropism.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 57 citations in OpenAlex.
- Adaptive variations in SARS-CoV-2 spike proteins: effects on distinct virus-cell entry stages.mBio · 2023Article
- Insights into coronavirus immunity taught by the murine coronavirus.European journal of immunology · 2021Review
- Murine-β-coronavirus-induced neuropathogenesis sheds light on CNS pathobiology of SARS-CoV2.Journal of neurovirology · 2021Review
- Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression.Journal of virology · 2020Article
- Suppression subtractive hybridization method for the identification of a new strain of murine hepatitis virus from xenografted SCID mice.Archives of virology · 2015Article
- MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus.Journal of virology · 2015Article
- The nsp1, nsp13, and M proteins contribute to the hepatotropism of murine coronavirus JHM.WU.Journal of virology · 2015Article
- Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus.Journal of virology · 2013Article
- Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology.Cell host & microbe · 2012Article
- Review
- Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus.Journal of virology · 2011Article
- Coronavirus pathogenesis.Advances in virus research · 2011Review
- Murine coronavirus neuropathogenesis: determinants of virulence.Journal of neurovirology · 2010Review
- Murine coronavirus receptors are differentially expressed in the central nervous system and play virus strain-dependent roles in neuronal spread.Journal of virology · 2010Article
- Genetic determinants of mouse hepatitis virus strain 1 pneumovirulence.Journal of virology · 2010Article
- Pathogenesis of murine coronavirus in the central nervous system.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- The murine coronavirus nucleocapsid gene is a determinant of virulence.Journal of virology · 2010Article
- Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2.Journal of virology · 2009Article
- Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microglia.Journal of virology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recombinant murine coronaviruses, differing only in the spike gene and containing the strain A59 (moderately hepatotropic) and JHM (neurotropic) spike genes in the background of the JHM genome, were compared for the ability to replicate in the liver and induce hepatitis in weanling C57BL/6 mice. Interestingly, expression of the A59 spike glycoprotein within the background of the neurotropic JHM strain does not reproduce the A59 hepatotropic phenotype. Thus, the JHM genetic background plays a dominant role over the spike in the determination of hepatotropism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.