ArticleJournal of virology2003
Changes in rhinovirus protein 2C allow efficient replication in mouse cells.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Human Stimulator of Interferon Genes Promotes Rhinovirus C Replication in Mouse Cells In Vitro and In Vivo.Viruses · 2024Article
- Adjuvant-independent airway sensitization and infection mouse models leading to allergic asthma.Frontiers in allergy · 2024Review
- Review
- Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- Surviving Deadly Lung Infections: Innate Host Tolerance Mechanisms in the Pulmonary System.Frontiers in immunology · 2018Review
- Mutations in VP1 and 3A proteins improve binding and replication of rhinovirus C15 in HeLa-E8 cells.Virology · 2016Article
- Involvement of a joker mutation in a polymerase-independent lethal mutagenesis escape mechanism.Virology · 2016Article
- Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Selection of rhinovirus 1A variants adapted for growth in mouse lung epithelial cells.Virology · 2011Article
- A host-specific, temperature-sensitive translation defect determines the attenuation phenotype of a human rhinovirus/poliovirus chimera, PV1(RIPO).Journal of virology · 2011Article
- Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract.Journal of virology · 2011Article
- Directed adenovirus evolution using engineered mutator viral polymerases.Nucleic acids research · 2011Article
- A mutant of infectious Asia 1 serotype foot-and-mouth disease virus with the deletion of 10-amino-acid in the 3A protein.Virus genes · 2010Article
- Article
- Human rhinovirus 14 enters rhabdomyosarcoma cells expressing icam-1 by a clathrin-, caveolin-, and flotillin-independent pathway.Journal of virology · 2010Article
- Serial culture of murine primary airway epithelial cells and ex vivo replication of human rhinoviruses.Journal of immunological methods · 2008Article
- Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice.American journal of respiratory and critical care medicine · 2008Article
- Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation.Nature medicine · 2008Article
- Molecular basis for a lack of correlation between viral fitness and cell killing capacity.PLoS pathogens · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Rhinovirus type 16 was found to replicate in mouse L cells that express the viral receptor, human intercellular adhesion molecule 1 (ICAM-1). However, infection of these cells at a low multiplicity of infection leads to no discernible cytopathic effect, and low virus titers are produced. A variant virus, 16/L, was isolated after alternate passage of rhinovirus 16 between HeLa and ICAM-1 L cells. Infection of mouse cells with 16/L leads to higher virus titers, increased production of RNA, and total cytopathic effect. Three amino acid changes were identified in the P2 region of virus 16/L, and the adaptation phenotype mapped to two changes in protein 2C. The characterization of a rhinovirus host range mutant will facilitate the investigation of cellular proteins required for efficient viral growth and the development of a murine model for rhinovirus infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.