ArticleGenetics2003
Mapping quantitative trait loci in the case of a spike in the phenotype distribution.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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72 citing papers in PubMed.
- Genetic mapping identifies QTL and candidate genes including Mendel's A gene controlling high levels of partial resistance to Fusarium avenaceum in Pea.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Periaxin gene variants are linked to age-related cataracts in Cx46 deficient lenses.Communications biology · 2025Article
- High-density genetic map construction and QTL analysis of the first flower node in kenaf using RAD-seq.BMC plant biology · 2024Article
- Baby makes three: Maternal, paternal, and zygotic genetic effects shape larval phenotypic evolution.Evolution; international journal of organic evolution · 2021Article
- Characterization of black spot resistance in diploid roses with QTL detection, meta-analysis and candidate-gene identification.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Reproductive and genetic roles of the maternal progenitor in the origin of common wheat (Ecology and evolution · 2020Article
- Strain-Dependent Modifier Genes Determine Survival inG3 (Bethesda, Md.) · 2020Article
- Genetic determinism of prickles in rose.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- A new source of root-knot nematode resistance from Arachis stenosperma incorporated into allotetraploid peanut (Arachis hypogaea).Scientific reports · 2019Article
- A Statistical Procedure for Genome-Wide Detection of QTL Hotspots Using Public Databases with Application to Rice.G3 (Bethesda, Md.) · 2019Article
- A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus.BMC neuroscience · 2018Article
- Exploring the genetics of fertility restoration controlled by Rf1 in common wheat (Triticum aestivum L.) using high-density linkage maps.Molecular genetics and genomics : MGG · 2018Article
- A New Diagnostic Resource forG3 (Bethesda, Md.) · 2017Article
- Article
- A Chromosome-Scale Assembly of theG3 (Bethesda, Md.) · 2017Article
- Genetic Architecture of Capitate Glandular Trichome Density in Florets of Domesticated Sunflower (Frontiers in plant science · 2017Article
- Quantitative trait loci controlling leaf appearance and curd initiation of cauliflower in relation to temperature.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Sample size and power calculations for detecting changes in malaria transmission using antibody seroconversion rate.Malaria journal · 2015Article
- Dominant Epistasis Between Two Quantitative Trait Loci Governing Sporulation Efficiency in YeastFood technology and biotechnology · 2015Article
- Identification and Correction of Sample Mix-Ups in Expression Genetic Data: A Case Study.G3 (Bethesda, Md.) · 2015Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A common departure from the usual normality assumption in QTL mapping concerns a spike in the phenotype distribution. For example, in measurements of tumor mass, some individuals may exhibit no tumors; in measurements of time to death after a bacterial infection, some individuals may recover from the infection and fail to die. If an appreciable portion of individuals share a common phenotype value (generally either the minimum or the maximum observed phenotype), the standard approach to QTL mapping can behave poorly. We describe several alternative approaches for QTL mapping in the case of such a spike in the phenotype distribution, including the use of a two-part parametric model and a nonparametric approach based on the Kruskal-Wallis test. The performance of the proposed procedures is assessed via computer simulation. The procedures are further illustrated with data from an intercross experiment to identify QTL contributing to variation in survival of mice following infection with Listeria monocytogenes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.