ArticleGenetics2003
Coupled mutagenesis screens and genetic mapping in zebrafish.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Article
- Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish.G3 (Bethesda, Md.) · 2022Article
- Involvement of transmembrane protein 184a during angiogenesis in zebrafish embryos.Frontiers in physiology · 2022Article
- Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish.Genome biology · 2021Article
- From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics.Pigment cell & melanoma research · 2017Review
- Novel Heparin Receptor Transmembrane Protein 184a Regulates Angiogenesis in the Adult Zebrafish Caudal Fin.Frontiers in physiology · 2017Article
- Functional assessment of human coding mutations affecting skin pigmentation using zebrafish.PloS one · 2012Article
- Generation of highly homogeneous strains of zebrafish through full sib-pair mating.G3 (Bethesda, Md.) · 2011Article
- Evidence for a core gut microbiota in the zebrafish.The ISME journal · 2011Article
- Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer.Disease models & mechanisms · 2011Article
- Article
- Osteoblast maturation occurs in overlapping proximal-distal compartments during fin regeneration in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- A gain of function mutation causing skeletal overgrowth in the rapunzel mutant.Developmental biology · 2009Article
- Zebrafish endzone regulates neural crest-derived chromatophore differentiation and morphology.PloS one · 2008Article
- Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration.Developmental biology · 2008Article
- Zebrafish melanophilin facilitates melanosome dispersion by regulating dynein.Current biology : CB · 2007Article
- Rapid genetic mapping in Neurospora crassa.Fungal genetics and biology : FG & B · 2007Article
- Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish.PLoS genetics · 2007Article
- Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a.PLoS genetics · 2007Article
- Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structure.Cell metabolism · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Forward genetic analysis is one of the principal advantages of the zebrafish model system. However, managing zebrafish mutant lines derived from mutagenesis screens and mapping the corresponding mutations and integrating them into the larger collection of mutations remain arduous tasks. To simplify and focus these endeavors, we developed an approach that facilitates the rapid mapping of new zebrafish mutations as they are generated through mutagenesis screens. We selected a minimal panel of 149 simple sequence length polymorphism markers for a first-pass genome scan in crosses involving C32 and SJD inbred lines. We also conducted a small chemical mutagenesis screen that identified several new mutations affecting zebrafish embryonic melanocyte development. Using our first-pass marker panel in bulked-segregant analysis, we were able to identify the genetic map positions of these mutations as they were isolated in our screen. Rapid mapping of the mutations facilitated stock management, helped direct allelism tests, and should accelerate identification of the affected genes. These results demonstrate the efficacy of coupling mutagenesis screens with genetic mapping.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.