ArticleGenetics2003
Evidence for inversion polymorphism related to sympatric host race formation in the apple maggot fly, Rhagoletis pomonella.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.
- Beyond trophic morphology: stable isotopes reveal ubiquitous versatility in marine turtle trophic ecology.Biological reviews of the Cambridge Philosophical Society · 2019Pooled it
- Genetic Divergence in the Absence of Strong Ecological Differences Between Coexisting White and Common Atlantic Marine Stickleback.Ecology and evolution · 2026Article
- Large Inversion Polymorphisms are Widespread in North American Songbirds.Genome biology and evolution · 2025Article
- Structural Variants and Speciation: Multiple Processes at Play.Cold Spring Harbor perspectives in biology · 2024Review
- Postzygotic barriers persist despite ongoing introgression in hybridizing Mimulus species.Molecular ecology · 2024Article
- Divergence in cell cycle progression is associated with shifted phenology in a multivoltine moth: the European corn borer, Ostrinia nubilalis.The Journal of experimental biology · 2023Article
- Sympatric or micro-allopatric speciation in a glacial lake? Genomic islands support neither.National science review · 2022Article
- A chromosomal inversion contributes to divergence in multiple traits between deer mouse ecotypes.Science (New York, N.Y.) · 2022Article
- Does the Pachytene Checkpoint, a Feature of Meiosis, Filter Out Mistakes in Double-Strand DNA Break Repair and as a side-Effect Strongly Promote Adaptive Speciation?Integrative organismal biology (Oxford, England) · 2022Article
- Review
- Haplotype tagging reveals parallel formation of hybrid races in two butterfly species.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Origin of Species before Origin of Life: The Role of Speciation in Chemical Evolution.Life (Basel, Switzerland) · 2021Review
- Can the genomics of ecological speciation be predicted across the divergence continuum from host races to species? A case study inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Tadpoles of hybridising fire-bellied toads (B. bombina and B. variegata) differ in their susceptibility to predation.PloS one · 2020Article
- Frequency, Origins, and Evolutionary Role of Chromosomal Inversions in Plants.Frontiers in plant science · 2020Review
- Host plant-related genomic differentiation in the European cherry fruit fly, Rhagoletis cerasi.Molecular ecology · 2019Article
- Geographic contrasts between pre- and postzygotic barriers are consistent with reinforcement in Heliconius butterflies.Evolution; international journal of organic evolution · 2019Article
- Standing geographic variation in eclosion time and the genomics of host race formation inEcology and evolution · 2019Article
- Chromosomal variation among populations of a fungus-farming ant: implications for karyotype evolution and potential restriction to gene flow.BMC evolutionary biology · 2018Article
- Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggests that the apple maggot, Rhagoletis pomonella (Diptera: Tephritidae) is undergoing sympatric speciation (i.e., divergence without geographic isolation) in the process of shifting and adapting to a new host plant. Prior to the introduction of cultivated apples (Malus pumila) in North America, R. pomonella infested the fruit of native hawthorns (Crataegus spp.). However, sometime in the mid-1800s the fly formed a sympatric race on apple. The recently derived apple-infesting race shows consistent allele frequency differences from the hawthorn host race for six allozyme loci mapping to three different chromosomes. Alleles at all six of these allozymes correlate with the timing of adult eclosion, an event dependent on the duration of the overwintering pupal diapause. This timing difference differentially adapts the univoltine fly races to an approximately 3- to 4-week difference in the peak fruiting times of apple and hawthorn trees, partially reproductively isolating the host races. Here, we report finding substantial gametic disequilibrium among allozyme and complementary DNA (cDNA) markers encompassing the three chromosomal regions differentiating apple and hawthorn flies. The regions of disequilibrium extend well beyond the previously characterized six allozyme loci, covering substantial portions of chromosomes 1, 2, and 3 (haploid n = 6 in R. pomonella). Moreover, significant recombination heterogeneity and variation in gene order were observed among single-pair crosses for each of the three genomic regions, implying the existence of inversion polymorphism. We therefore have evidence that genes affecting diapause traits involved in host race formation reside within large complexes of rearranged genes. We explore whether these genomic regions (inversions) constitute coadapted gene complexes and discuss the implications of our findings for sympatric speciation in Rhagoletis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.