ArticleCirculation research2003
Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice.
Article in Circulation research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Retinol dehydrogenase 10-mediated retinoic acid signaling regulates the neural crest cell microenvironment during enteric nervous system formation.Human molecular genetics · 2026Article
- Retinoid Homeostasis and Beyond: How Retinol Binding Protein 4 Contributes to Health and Disease.Nutrients · 2022Review
- Patterning of vertebrate cardiac progenitor fields by retinoic acid signaling.Genesis (New York, N.Y. : 2000) · 2021Review
- Biological Functions of RBP4 and Its Relevance for Human Diseases.Frontiers in physiology · 2021Review
- Role of carotenoids and retinoids during heart development.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Review
- Recent insights on the role and regulation of retinoic acid signaling during epicardial development.Genesis (New York, N.Y. : 2000) · 2019Review
- Input overload: Contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Primary culture of avian embryonic heart forming region cells to study the regulation of vertebrate early heart morphogenesis by vitamin A.BMC developmental biology · 2014Article
- Maternal-fetal transfer and metabolism of vitamin A and its precursor β-carotene in the developing tissues.Biochimica et biophysica acta · 2012Review
- The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development.BMC developmental biology · 2011Article
- The membrane receptor for plasma retinol-binding protein, a new type of cell-surface receptor.International review of cell and molecular biology · 2011Review
- Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation.Development (Cambridge, England) · 2010Article
- The expanding role for retinoid signaling in heart development.TheScientificWorldJournal · 2008Review
- A1 adenosine receptors play an essential role in protecting the embryo against hypoxia.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Trichloroethylene exposure during cardiac valvuloseptal morphogenesis alters cushion formation and cardiac hemodynamics in the avian embryo.Environmental health perspectives · 2006Article
- Cardiac myocyte differentiation: the Nkx2.5 and Cripto target genes in P19 clone 6 cells.Functional & integrative genomics · 2005Article
- Analysis of the proepicardium-epicardium transition during the malformation of the RXRalpha-/- epicardium.Developmental dynamics : an official publication of the American Association of Anatomists · 2005Article
- Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation.The Biochemical journal · 2004Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Precise regulation of retinoid levels is critical for normal heart development. Retinol-binding protein (RBP), an extracellular retinol transporter, is strongly secreted by cardiogenic endoderm. This study addresses whether RBP gene ablation affects heart development. Despite exhibiting an >85% decrease in serum retinol, adult RBP-null mice are viable, breed, and have normal vision when maintained on a vitamin A-sufficient diet. Comparison of RBP-null with wild-type (WT) hearts from embryos at day 9.0 (E9.0) through E12.5 revealed an RBP-null phenotype similar to that of other retinoid-deficient models. At an early stage, RBP-null hearts display retarded trabecular development, which recovers by E9.5. This is accompanied at E9.5 and E10.5 by precocious differentiation of subepicardial cardiac myocytes. Most remarkably, RBP-null hearts display augmented deposition of fibronectin protein in the cardiac jelly at E9.0 through E10.5 and in the outflow tract at E12.5. This phenomenon, which was detected by immunohistochemistry and Western blotting without increased fibronectin transcript levels, is accompanied by increased numbers of mesenchymal cells in the outflow tract but not in the atrioventricular canal. RBP-null cardiac myocytes, especially in the subepicardial layer, display increased cell proliferation. This phenotype may present a model of subclinical retinoid insufficiency characterized by alteration of an extracellular matrix component and altered cellular differentiation and proliferation, changes that may have functional consequences for adult cardiac function. This murine model may have relevance to fetal development in human populations with inadequate retinoid intake.
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