ArticleBMJ (Clinical research ed.)2003
Increase in blood glucose concentration during antihypertensive treatment as a predictor of myocardial infarction: population based cohort study.
Article in BMJ (Clinical research ed.), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- THE IMPACT OF CARDIOVASCULAR DRUGS ON GLYCEMIC CONTROL: A REVIEW.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2017Pooled it
- Predictors for glucose change in hypertensive participants following short-term treatment with atenolol or hydrochlorothiazide.Pharmacotherapy · 2014Trial
- Impact of abdominal obesity on incidence of adverse metabolic effects associated with antihypertensive medications.Hypertension (Dallas, Tex. : 1979) · 2010Trial
- Antihypertensive drug class and impaired fasting glucose: a risk association study among Chinese patients with uncomplicated hypertension.BMC clinical pharmacology · 2008Trial
- Exploring the mechanism of Yixinyin for myocardial infarction by weighted co-expression network and molecular docking.Scientific reports · 2021Article
- Emerging Applications of Metabolomics in Traditional Chinese Medicine Treating Hypertension: Biomarkers, Pathways and More.Frontiers in pharmacology · 2019Review
- Population-based cardiovascular cohort studies in Uppsala.Upsala journal of medical sciences · 2019Review
- Alpha Adducin (ADD1) Gene Polymorphism and New Onset of Diabetes Under the Influence of Selective Antihypertensive Therapy in Essential Hypertension.Current hypertension reviews · 2019Article
- Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases.Scientific reports · 2018Article
- Drug-Induced Hyperglycaemia and Diabetes.Drug safety · 2015Review
- The effects of antihypertensive drugs on chromium status, glucose metabolism, and antioxidant and inflammatory indices in spontaneously hypertensive rats.Biological trace element research · 2014Article
- The DASH diet and insulin sensitivity.Current hypertension reports · 2011Review
- Stopping the cardiovascular disease continuum: Focus on prevention.World journal of cardiology · 2010Article
- Antihypertensive medications: benefits of blood pressure lowering and hazards of metabolic effects.Expert review of cardiovascular therapy · 2009Review
- Using diuretics in practice--one opinion.Journal of clinical hypertension (Greenwich, Conn.) · 2008Article
- Beta-blockers in hypertension: truths and half-truths.Journal of clinical hypertension (Greenwich, Conn.) · 2008Article
- Summary of the 2007 European Society of Hypertension (ESH) and European Society of Cardiology (ESC) guidelines for the management of arterial hypertension.Vascular health and risk management · 2007Review
- Antihypertensive medications and blood sugar: theories and implications.The Canadian journal of cardiology · 2006Review
- Is the development of diabetes with antihypertensive therapy a problem?--Pro.Journal of clinical hypertension (Greenwich, Conn.) · 2006Review
- New-onset diabetes in treated hypertensive patients.Current hypertension reports · 2005Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the impact of an increase in blood glucose on the risk of developing myocardial infarction, with particular emphasis on people taking antihypertensive drugs.
designProspective population based cohort study.
settingUppsala, Sweden.
participants1860 men who had participated in 1970-3 at age 50 in a health survey aimed at identifying risk factors for cardiovascular disease and were re-examined at age 60 and then followed for 17.4 years. MIN OUTCOME MEASURE: Myocardial infarction after age 60.
resultsThe incidence of myocardial infarction was significantly higher in men treated for hypertension than in those without such treatment (23% v 13.5%, P<0.0001). Participants who developed myocardial infarction after the age of 60 (n=253) showed a significantly larger increase in blood glucose between age 50 and 60 than did those without myocardial infarction. In multivariate Cox proportional hazard models increase in blood glucose was an independent risk factor for myocardial infarction (P=0.0001) in men receiving antihypertensive treatment at age 60 (n=291, mainly beta blockers and thiazide diuretics) but not in those without such treatment. The impact of increase in blood glucose declined after inclusion of serum proinsulin concentrations at baseline but was still significant. A significant interaction existed between proinsulin concentration (a marker of insulin resistance) at baseline and antihypertensive treatment on increase in blood glucose.
conclusionsIncrease in blood glucose between the ages of 50 and 60 and baseline proinsulin concentration were important risk factors for myocardial infarction in men receiving antihypertensive treatment, indicating that both an insulin resistant state and the metabolic impact of beta blockers and diuretics increase the risk of myocardial infarction.
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