ArticleOncogene2003
Expression of an Ets-1 dominant-negative mutant perturbs normal and tumor angiogenesis in a mouse ear model.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Review
- iTRAQ-based quantitative proteomic analysis of thoracic aortas from adult rats born to preeclamptic dams.Clinical proteomics · 2021Article
- Biophysical Techniques for Target Validation and Drug Discovery in Transcription-Targeted Therapy.International journal of molecular sciences · 2020Review
- Ets-1 drives breast cancer cell angiogenic potential and interactions between breast cancer and endothelial cells.International journal of oncology · 2019Article
- A bipolar role of the transcription factor ERG for cnidarian germ layer formation and apical domain patterning.Developmental biology · 2017Article
- ETS transcription factors in embryonic vascular development.Angiogenesis · 2016Review
- Towards the Design of a Patient-Specific Virtual Tumour.Computational and mathematical methods in medicine · 2016Article
- Understanding the role of ETS-mediated gene regulation in complex biological processes.Advances in cancer research · 2013Review
- Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma.Pigment cell & melanoma research · 2011Article
- The role of ets factors in tumor angiogenesis.Journal of oncology · 2010Article
- Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling.Cancer research · 2008Article
- Ets-1 regulates radial glia formation during vertebrate embryogenesis.Organogenesis · 2007Article
- Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1.Journal of virology · 2007Article
- The proinflammatory cytokines IL-1beta and TNF-alpha induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway.Arthritis research & therapy · 2006Article
- Ets-1 expression promotes epithelial cell transformation by inducing migration, invasion and anchorage-independent growth.Oncogene · 2005Article
- The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis.Oncogene · 2005Article
- SP100 inhibits ETS1 activity in primary endothelial cells.Oncogene · 2005Article
- ETS transcription factors: possible targets for cancer therapy.Cancer science · 2004Review
- Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.The American journal of pathology · 2004Article
- The biology of the Ets1 proto-oncogene.Molecular cancer · 2003Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We and others have shown that members of the Ets family of transcription factors are involved in morphogenic properties of endothelial cells in vitro. To investigate the role of these factors in the transcriptional regulation of angiogenesis in vivo, we set up a nontraumatic model that allows daily macroscopic examination of both growth factor- and tumor-induced angiogenesis in mouse ears. In the same animal, we were thus able to record variations in the patterns of neovessels induced and cell populations recruited by the angiogenic factors FGF-2 and VEGF. In this model, inhibition of FGF-2-induced angiogenesis by the pharmacological compound TNP-470 was readily observed, demonstrating that the mouse ear model is also useful in the evaluation of antiangiogenic strategies. Our functional analysis of Ets transcription factors activity utilized a competitor protein, Ets1-DB, a dominant negative Ets1 mutant lacking the transactivation domain. Retrovirus-mediated expression of Ets1-DB inhibited FGF-2-induced angiogenesis, while the expression of Ets1-DB in cancerous and stromal cells disturbed tumor-induced angiogenesis. These results illustrate the value of the ear model and highlight the role of Ets family members in the transcriptional regulation of tumor angiogenesis.
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