ArticleMolecular psychiatry2003
Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci.
Article in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Role of dopamine receptors in ADHD: a systematic meta-analysis.Molecular neurobiology · 2012Pooled it
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- Variants of Dopamine Beta Hydroxylase Gene Moderate Atomoxetine Response in Children with Attention-Deficit/Hyperactivity Disorder.Journal of child and adolescent psychopharmacology · 2015Trial
- Dopamine transporter haplotype and attention-deficit hyperactivity disorder.Molecular psychiatry · 2005Trial
- Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention.Neuroscience · 2019Article
- Separating the wheat from the chaff: systematic identification of functionally relevant noncoding variants in ADHD.Molecular psychiatry · 2016Article
- Lack of association of polymorphisms in six candidate genes in colombian adhd patients.Annals of neurosciences · 2015Article
- Association study of dopamine transporter gene (DAT1) variable tandem repeat sequence (VNTR) with obsessive-compulsive disorder in Chinese Han Population.International journal of clinical and experimental medicine · 2015Article
- Association of dopamine transporter gene variants with childhood ADHD features in bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Article
- Epistasis between neurochemical gene polymorphisms and risk for ADHD.European journal of human genetics : EJHG · 2011Article
- Study on DBH genetic polymorphisms and plasma activity in attention deficit hyperactivity disorder patients from Eastern India.Cellular and molecular neurobiology · 2010Article
- Molecular genetics of attention deficit hyperactivity disorder.The Psychiatric clinics of North America · 2010Review
- Genome-wide linkage analysis in a Dutch multigenerational family with attention deficit hyperactivity disorder.European journal of human genetics : EJHG · 2010Article
- SNP discovery and haplotype analysis in the segmentally duplicated DRD5 coding region.Annals of human genetics · 2009Article
- Correlation of plasma dopamine beta-hydroxylase activity with polymorphisms in DBH gene: a study on Eastern Indian population.Cellular and molecular neurobiology · 2008Article
- Genetic aspects in attention-deficit/hyperactivity disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2008Review
- Association and linkage of allelic variants of the dopamine transporter gene in ADHD.Molecular psychiatry · 2007Article
- The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.Molecular psychiatry · 2006Article
- Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5.Molecular psychiatry · 2004Article
- Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes.American journal of human genetics · 2004Article
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormalities in dopaminergic neurotransmission are now accepted as factors in predisposing to ADHD. Evidence of associations between dopamine transporter gene polymorphism and ADHD was first reported by Cook et al. We confirmed the DAT1 association and also identified two additional susceptibility loci at the DRD5 and DBH. Notably, none of the associated variants at these three genes are known to be expressed. Other variants within or closely mapped to the associated alleles are likely to be relevant. In this investigation, we analyse additional markers creating a high-density map across and flanking these genes, and measure intermarker linkage disequilibrium (LD). None of the newly examined markers were more strongly associated with ADHD. At DAT1, the pattern of intermarker LD and haplotype association with the phenotype between exon 9 and the 3' of the gene suggests that the functional variant at DAT1 may be located to this region. For DRD5, three markers, covering a region of approximately 68 kb including the single DRD5 exon are all associated with disease, and thus do not provide localizing information. However, the data for DBH point to a region close to the centre of the gene. Correlation between D' and physical distance was observed between markers at DAT1 and DRD5 for distances less than 50 kb. This was not the case for DBH, where LD breakdown was observed between the intron 5 and intron 9 polymorphisms although they are only 9 kb apart. Further genetic analysis is unlikely to refine the location of susceptibility variants and functional assessment of variants within associated regions is required.
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