ArticleThe EMBO journal2003
The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 56 citations in OpenAlex.
- Rap1-mediated steric hindrance protects telomeres from MRX sensing.Nature structural & molecular biology · 2026Article
- The adaptive molecular landscape of reprogrammed telomeric sequences.Nature communications · 2026Article
- Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing.Genome research · 2022Article
- Article
- The role of Rif1 in telomere length regulation is separable from its role in origin firing.eLife · 2020Article
- Co-evolution in the Jungle: From Leafcutter Ant Colonies to Chromosomal Ends.Journal of molecular evolution · 2020Review
- Review
- Commentary: Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function.Frontiers in genetics · 2018Article
- Double-stranded telomeric DNA binding proteins: Diversity matters.Cell cycle (Georgetown, Tex.) · 2017Review
- Evolution of Telomeres in Schizosaccharomyces pombe and Its Possible Relationship to the Diversification of Telomere Binding Proteins.PloS one · 2016Article
- Telomeric repeats act as nucleosome-disfavouring sequences in vivo.Nucleic acids research · 2014Article
- The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres.Cell cycle (Georgetown, Tex.) · 2014Article
- The length of the shortest telomere as the major determinant of the onset of replicative senescence.Genetics · 2013Article
- Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency.Nucleic acids research · 2013Article
- Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break ends.The EMBO journal · 2013Article
- Identification of telomerase RNAs from filamentous fungi reveals conservation with vertebrates and yeasts.PloS one · 2013Article
- One identity or more for telomeres?Frontiers in oncology · 2013Article
- "Poisoning" yeast telomeres distinguishes between redundant telomere capping pathways.Chromosoma · 2012Article
- DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1.The EMBO journal · 2012Article
- Subtelomere-binding protein Tbf1 and telomere-binding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast.Molecular biology of the cell · 2012Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of telomeric DNA repeats at chromosome ends is maintained around a mean value by a dynamic balance between elongation and shortening. In particular, proteins binding along the duplex part of telomeric DNA set the number of repeats by progressively limiting telomere growth. The paradigm of this counting mechanism is the Rap1 protein in Saccharomyces cerevisiae. We demonstrate here that a Rap1-independent mechanism regulates the number of yeast telomeric repeats (TG(1-3)) and of vertebrate repeats (T(2)AG(3)) when TEL1, a yeast ortholog of the human gene encoding the ATM kinase, is inactivated. In addition, we show that a T(2)AG(3)-only telomere can be formed and maintained in humanized yeast cells carrying a template mutation of the gene encoding the telomerase RNA, which leads to the synthesis of vertebrate instead of yeast repeats. Genetic and biochemical evidences indicate that this telomere is regulated in a Rap1-independent manner, both in TEL1 and in tel1Delta humanized yeast cells. Altogether, these findings shed light on multiple repeat-counting mechanisms, which may share critical features between lower and higher eukaryotes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.