ArticleNeoplasia (New York, N.Y.)
Cytogenetic profile of unknown primary tumors: clues for their pathogenesis and clinical management.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- A Systematic Review of Cancer of Unknown Primary in the Head and Neck Region.Cancer management and research · 2021Review
- Cancer of Unknown Primary Site: Real Entity or Misdiagnosed Disease?Journal of Cancer · 2020Review
- Does Cancer of Unknown Primary (CUP) Truly Exist as a Distinct Cancer Entity?Frontiers in oncology · 2019Review
- Cancers of unknown primary origin (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin.BMC cancer · 2015Article
- [Cancer of unknown primary. Epidemiology and pathogenesis].Der Radiologe · 2014Article
- [CUP syndrome: molecular pathogenesis and biology].Der Pathologe · 2009Article
- Metastases in the Absence of a Primary Tumor: Advances in the Diagnosis and Treatment of CUP Syndrome.Deutsches Arzteblatt international · 2008Article
- Biological characterization of two xenografts derived from human CUPs (carcinomas of unknown primary).BMC cancer · 2007Article
- Carcinoma of unknown primary origin.Gastrointestinal cancer research : GCR · 2007Article
- A review of the past, present, and future directions of neoplasia.Neoplasia (New York, N.Y.) · 2005Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unknown primary tumors (UPTs) represent an entity of great clinical and biological interest, whose origin cannot be determined even after medical workup. To better understand their pathogenesis by outlining their genetic composition, 20 UPTs were investigated by G-banding, supplemented with Fluorescence In Situ Hybridization and Comparative Genomic Hybridization analyses. The data obtained were sufficient to reach a diagnosis in five cases-four lymphomas and one Ewing sarcoma-demonstrating that in a subset of UPTs, cytogenetics can be an adjunct for differential diagnosis. In the remaining 15 UPTs, an aggressive cytogenetic pattern was revealed. The most frequently rearranged chromosome regions were 1q21, 3p13, 6q15-23, 7q22, 11p12-5, and 11q14-24, pinpointing gene loci probably associated with the peculiar pathogenesis of UPTs. The preferential involvement of 4q31, 6q15, 10q25, and 13q22 in adenocarcinomas (whereas 11q22 is involved in the rest of the carcinomas)-in addition to the marked divergence in the mean average of chromosomal changes, 16 and 3, respectively-demonstrates genotypic differences between the two histologic subgroups. Furthermore, the significantly shorter survival in cases displaying massive chromosome changes compared with those having a few changes indicates that the cytogenetic pattern might be used as a tool to assess prognosis in UPTs, even without the detection of their primary site.
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