ArticleThe Biochemical journal2003
Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Targeting Focal Adhesion Kinase in Lung Diseases: Current Progress and Future Directions.Biomolecules · 2025Review
- Constitutive activation of integrin αvβ3 contributes to anoikis resistance of ovarian cancer cells.Molecular oncology · 2021Article
- Focal adhesion kinase promotes progression and predicts poor clinical outcomes in patients with osteosarcoma.Oncology letters · 2018Article
- Cbl-b promotes cell detachment via ubiquitination of focal adhesion kinase.Oncology letters · 2016Article
- Breast Cancer Malignant Processes are Regulated by Pax-5 Through the Disruption of FAK Signaling Pathways.Journal of Cancer · 2016Article
- Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.The Journal of biological chemistry · 2015Article
- Targeting the p53 pathway.Surgical oncology clinics of North America · 2013Review
- Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeutics.Science signaling · 2013Review
- Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.The Journal of biological chemistry · 2012Article
- FAK and p53 protein interactions.Anti-cancer agents in medicinal chemistry · 2011Review
- Suppression of human MDA-MB-435S tumor by U6 promoter-driven short hairpin RNAs targeting focal adhesion kinase.Journal of cancer research and clinical oncology · 2010Article
- Focal adhesion kinase and p53 signal transduction pathways in cancer.Frontiers in bioscience (Landmark edition) · 2010Review
- Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin.Alcoholism, clinical and experimental research · 2010Article
- Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma.Cell cycle (Georgetown, Tex.) · 2010Article
- Focal adhesion kinase as an immunotherapeutic target.Cancer immunology, immunotherapy : CII · 2009Article
- Focal adhesion kinase versus p53: apoptosis or survival?Science signaling · 2008Review
- A systems biology approach for pathway level analysis.Genome research · 2007Article
- Cis-hydroxyproline-induced inhibition of pancreatic cancer cell growth is mediated by endoplasmic reticulum stress.World journal of gastroenterology · 2006Article
- Construction of retroviral vector of p(125FAK) specific ribozyme genes and its effects on BGC-823 cells.World journal of gastroenterology · 2006Article
- Specific induction of pp125 focal adhesion kinase in human breast cancer.British journal of cancer · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Focal adhesion kinase (FAK) has a central role in adhesion-mediated cell signalling. The N-terminus of FAK is thought to function as a docking site for a number of proteins, including the Src-family tyrosine kinases. In the present study, we disrupted FAK signalling by expressing the N-terminal domain of FAK (FAK-NT) in human breast carcinoma cells, BT474 and MCF-7 lines, and non-malignant epithelial cells, MCF-10A line. Expression of FAK-NT led to rounding, detachment and apoptosis in human breast cancer cells. Apoptosis was accompanied by dephosphorylation of FAK Tyr(397), degradation of the endogenous FAK protein and activation of caspase-3. Over-expression of FAK rescued FAK-NT-mediated cellular rounding. Expression of FAK-NT in non-malignant breast epithelial cells did not lead to rounding, loss of FAK phosphorylation or apoptosis. Thus FAK-NT contributes to cellular adhesion and survival pathways in breast cancer cells which are not required for survival in non-malignant breast epithelial cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.