Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Patterned sensory stimulation induces plasticity in reciprocal ia inhibition in humans.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Superior efficacy of 100-Hz transcutaneous electrical nerve stimulation in reducing post-stroke spasticity: a systematic review and meta-analysis.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Effect of electrical stimulation on muscle atrophy and spasticity in patients with spinal cord injury - a systematic review with meta-analysis.Spinal cord · 2019Pooled it
- High-Intensity Gait Training With Functional Electrical Stimulation Enhances Corticospinal Excitability of Paretic Ankle Muscles in Individuals Post-Stroke.Neural plasticity · 2025Trial
- Concomitant sensory stimulation during therapy to enhance hand functional recovery post stroke.Trials · 2022Trial
- Feasibility and potential effects of using the electro-dress Mollii on spasticity and functioning in chronic stroke.Journal of neuroengineering and rehabilitation · 2020Trial
- Task-Specific and Functional Effects of Speed-Focused Elliptical or Motor-Assisted Cycle Training in Children With Bilateral Cerebral Palsy: Randomized Clinical Trial.Neurorehabilitation and neural repair · 2017Trial
- Short-term plasticity of human spinal inhibitory circuits after isometric and isotonic ankle training.European journal of applied physiology · 2013Trial
- Spinal use-dependent plasticity of synaptic transmission in humans after a single cycling session.The Journal of physiology · 2007Trial
- Focal Task-Specific Dystonia Beyond M1: Network Adaptations and a Causal-Architecture Taxonomy of Dystonia.Brain sciences · 2026Article
- Immediate Effects of Transcutaneous Spinal Stimulation on Stretch-Induced Spasticity in Persons with Spinal Cord Injury.Brain sciences · 2025Article
- Transcutaneous Spinal Stimulation Modulates Spinal Reflex Circuit Excitability in Persons with Spinal Cord Injury.Biomedicines · 2025Article
- Spinal excitability following sensory electrical stimulation of the upper limb.Physiological reports · 2025Article
- Modulation of Primary Afferent Nerve Fiber (Ia) Reciprocal Inhibition Under Voluntary and Electrically Stimulated Muscle Conditions: Within-Subject Study Design.Journal of clinical medicine · 2025Article
- Transcutaneous spinal cord stimulation neuromodulates pre- and postsynaptic inhibition in the control of spinal spasticity.Cell reports. Medicine · 2024Article
- Transcutaneous spinal cord stimulation phase-dependently modulates spinal reciprocal inhibition induced by pedaling in healthy individuals.Experimental brain research · 2024Article
- The Use of TheraBracelet Upper Extremity Vibrotactile Stimulation in a Child with Cerebral Palsy-A Case Report.Electronics · 2024Article
- Assessing the Impact of Electrosuit Therapy on Cerebral Palsy: A Study on the Users' Satisfaction and Potential Efficacy.Brain sciences · 2023Article
- Seamlessly integrated textile electrodes and conductive routing in a garment for electrostimulation: design, manufacturing and evaluation.Scientific reports · 2023Article
- Participant attention on the intervention target during repetitive passive movement improved spinal reciprocal inhibition enhancement and joint movement function.European journal of medical research · 2023Article
- The Role of Transcranial Magnetic Stimulation, Peripheral Electrotherapy, and Neurophysiology Tests for Managing Incomplete Spinal Cord Injury.Biomedicines · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Training of spinal cord circuits using sensorimotor stimulation has been proposed as a strategy to improve movement after spinal injury. How sensory stimulation may lead to long-lasting changes is not well understood. We studied whether sensory stimulation might induce changes in the strength of a specific spinal interneuronal circuit: spinally mediated reciprocal Ia inhibition. In healthy humans, the strength of reciprocal inhibition between ankle flexor and extensor muscles was assessed before and after 30 min of peroneal nerve stimulation at motor threshold intensity. Three stimulation protocols were assessed: patterned nerve stimulation (10 pulses at 100 Hz every 1.5 sec), uniform nerve stimulation (one pulse every 150 msec), and combined stimulation of the peroneal nerve and the motor cortex with transcranial magnetic stimulation. Short-latency reciprocal inhibition from ankle flexor to extensor muscles was measured by conditioning the soleus H-reflex with stimulation of the common peroneal nerve. The strength of the reciprocal inhibition was measured at baseline and for 20 min after each stimulation session. Patterned stimulation, with or without motor cortex stimulation, enhanced reciprocal inhibition for at least 5 min afterward. The uniform pattern of stimulation was ineffective. These results demonstrate the presence of short-term plasticity within spinal inhibitory circuits. We conclude that the pattern of sensory input is a crucial factor for inducing changes in the spinal circuit for reciprocal inhibition in humans. These findings may have implications for the use of repetitive patterned sensory stimulation in rehabilitative efforts to improve walking ability in patients with spinal injury.
Indexed as
Identifiers
12657659PMC6742007W1906928334What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.